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首页> 外文期刊>Journal of dentistry >Three-dimensional profilometric assessment of early enamel erosion simulating gastric regurgitation
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Three-dimensional profilometric assessment of early enamel erosion simulating gastric regurgitation

机译：早期搪瓷侵蚀模拟胃反流的三维轮廓评估

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Objectives A priority research area in minimal intervention dentistry is the characterization of the early stages of dental erosion. The aim of this in vitro study was to assess the effect of short, repetitive erosive challenges to human enamel over 2 min at pH 1.5 and 3.0 under conditions simulating gastric regurgitation.Methods Enamel surfaces were subjected to erosive challenges at pH 1.5 (Group 1, n = 10) and pH 3.0 (Group 2, n = 9) for periods of 30 s (stage 1), 60 s (stage 2) and 120 s (stage 3). Quantitative changes were assessed longitudinally by measuring the 3D average surface roughness (Sa) values using 3D confocal microscopy. Qualitative micrographic assessment of surface changes was also conducted by using environmental scanning electron microscopy.Results Linear mixed model analysis showed significant effects of the pH values (p < 0.001) and the stages (p < 0.001) on the observed Sa values. Post hoc tests showed significant increases in the Sa values between baseline and other stages in both groups (p < 0.01). The mean Sa values also increased significantly from stage 1 to stage 2 in Group 1 (p < 0.05). Micrographic analysis displayed severely etched enamel rods in Group 1, but only subtle changes in Group 2.Conclusions The complexity of the enamel surface is influenced by both acid concentration (pH value) and duration of acid exposure during early stages of erosion. Erosion occurring under conditions simulating GORD can be detected in its initial stages, opening up the possibilities of early diagnosis and management of this condition.Clinical significance: Erosive tooth wear occurs progressively and insidiously, often creating complex treatment challenges. This emphasizes the need for early diagnosis and management in accordance with minimal intervention philosophy. Our findings provide a foundation for further research that could lead to the development of highly-sensitive clinical diagnostic tools and preventive strategies.
机译：目的在最小的干预牙科牙科的优先研究区是牙科侵蚀早期阶段的表征。这种体外研究的目的是评估在模拟胃重新静置的pH 1.5和3.0下在pH 1.5和3.0下在pH 1.5和3.0下对人牙釉质进行短暂，重复侵蚀挑战的影响。方法在pH 1.5（第1组， n = 10）和pH 3.0（第2组，n = 9），30 s（阶段1），60s（阶段2）和120s（第3阶段）。通过使用3D共聚焦显微镜测量3D平均表面粗糙度（SA）值来纵向评估定量变化。还通过使用环境扫描电子显微镜进行表面变化的定性显微图评估。结果线性混合模型分析显示PH值（P <0.001）和观察到的SA值上的阶段（P <0.001）的显着效果。后HOC测试显示出在两组基线和其他阶段之间的SA值显着增加（P <0.01）。平均SA值也从第1阶段到第1阶段显着增加（P <0.05）。显微镜分析在第1组中显示严重蚀刻的牙釉质棒，但仅在侵蚀期间渗透浓度（pH值）和酸暴露的持续性影响的微妙变化。在模拟GORD的条件下发生的侵蚀可以在其初始阶段中检测到，开辟这种情况的早期诊断和管理的可能性。临床意义：腐蚀性牙齿磨损逐渐发生，往往会产生复杂的治疗挑战。这强调了根据最小干预哲学的早期诊断和管理的需求。我们的调查结果为进一步研究提供了一个基础，可能导致高度敏感的临床诊断工具和预防策略的发展。

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