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首页> 外文期刊>Journal of dentistry >Ratio variables in regression analysis can give rise to spurious results: illustration from two studies in periodontology.
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Ratio variables in regression analysis can give rise to spurious results: illustration from two studies in periodontology.

机译：回归分析中的比率变量可以引起虚假结果：从牙周病学中的两项研究中的插图。

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OBJECTIVES: For over a century, statisticians have highlighted concerns about the inappropriate use of ratio variables in correlation and regression analysis. However, little attention has been paid to these concerns in medical and dental research. The use of ratio variables in correlation and regression analysis can give rise to spurious results due to inappropriate model specification and mathematical coupling, leading to serious misinterpretation of data and consequently to incorrect study conclusions. METHODS: Data were reanalysed from two recently published articles: one on the efficacy of guided tissue regeneration on root coverage; the other a randomised controlled trial comparing three surgical approaches in the treatment of periodontal infrabony defects. The reanalysis was performed to examine whether the assumptions behind the correlation/regression analyses have been seriously violated in these two studies, and to see if the interpretation of results is tenable. RESULTS: Use of ratio variables seriously violated the assumptions underpinning the statistical methods utilised in these two studies, and consequently the conclusions were substantially misleading. Recommendations made in these studies were not tenable. CONCLUSIONS: The reanalyses illustrate how the inappropriate use of ratio variables remains prevalent in dental research, leading to incorrect interpretation of the evidence. This emphasises the need for collaboration between clinicians and statisticians to avoid the risk of yielding erroneous conclusions from flawed statistical analyses.
机译：目标：超过一个世纪，统计学家突出了关于比率变量在相关性和回归分析中不恰当使用的担忧。但是，对医学和牙科研究的这些担忧已经提出了很少的关注。由于不适当的模型规范和数学耦合，使用比率变量的使用与回归分析可以引起虚假的结果，导致对数据的严重误解，从而误解了不正确的研究结论。方法：从最近发表的两篇文章中排列数据：一个关于引导组织再生对根覆盖的疗效;另一个随机对照试验比较了三种手术方法治疗牙周缺陷的缺陷。进行重新分析以检查在这两个研究中是否严重侵犯了相关/回归分析的假设，并了解结果的解释是宗旨。结果：使用比率变量严重违反了在这两项研究中使用的统计方法的假设，因此结论基本上是误导性的。在这些研究中提出的建议是不可遗赠的。结论：Reanalyses说明了牙科研究中的不恰当使用量变量如何普遍存在，导致对证据的解释不正确。这强调需要临床医生和统计学家之间的合作，以避免从缺陷的统计分析产生错误结论的风险。

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