Activation of PKB/Akt and p44/42 by mechanical stretch utilizes desmosomal structures and the keratin filament

Kippenberger Stefan; Kleemann Johannes; Meissner Markus; Steinhorst Katja; Mueller Jutta; Zouboulis Christos C.; Kaufmann Roland; Zoeller Nadja

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Activation of PKB/Akt and p44/42 by mechanical stretch utilizes desmosomal structures and the keratin filament

机译：通过机械拉伸激活PKB / AKT和P44 / 42利用去染色体结构和角蛋白丝

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Background: Mechanical stress is an ubiquitous challenge of human cells with fundamental impact on cell physiology. Previous studies have shown that stretching promotes signalling cascades involved in proliferation and tissue enlargement.

机译：背景：机械应力是人体细胞对细胞生理学的根本影响的普遍挑战。以前的研究表明，拉伸促进了参与增殖和组织扩大的信号传导级联。

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来源
《Journal of dermatological science》 |2018年第3期|共7页
作者
Kippenberger Stefan; Kleemann Johannes; Meissner Markus; Steinhorst Katja; Mueller Jutta; Zouboulis Christos C.; Kaufmann Roland; Zoeller Nadja;
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作者单位

Goethe Univ Frankfurt Clin Dermatol Venereol &

Allergol Frankfurt Germany;

Goethe Univ Frankfurt Clin Dermatol Venereol &

Allergol Frankfurt Germany;

Goethe Univ Frankfurt Clin Dermatol Venereol &

Allergol Frankfurt Germany;

Goethe Univ Frankfurt Clin Dermatol Venereol &

Allergol Frankfurt Germany;

Goethe Univ Frankfurt Clin Dermatol Venereol &

Allergol Frankfurt Germany;

Brandenburg Med Sch Theodor Fontane Dessau Med Ctr Dept Dermatol Dessau Germany;

Goethe Univ Frankfurt Clin Dermatol Venereol &

Allergol Frankfurt Germany;

Goethe Univ Frankfurt Clin Dermatol Venereol &

Allergol Frankfurt Germany;

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原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;
关键词
Mechanics; Keratin; Desmosomes; Epidermolysis bullosa;

机译：力学;角蛋白;DESMOSOMES;表皮神经分解BOLLOSA;

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专利

1. Activation of PKB/Akt and p44/42 by mechanical stretch utilizes desmosomal structures and the keratin filament [J] . Kippenberger Stefan, Kleemann Johannes, Meissner Markus, Journal of dermatological science . 2018,第3期

机译：通过机械拉伸激活PKB / AKT和P44 / 42利用去染色体结构和角蛋白丝
2. The effect of mechanical cell stretch on the ultrastructure of desmosomes and keratin filaments [J] . Abu-Omar B., Jung D., Walther P., Acta physiologica . 2019,第S719期

机译：机械细胞拉伸对去染色和角蛋白长丝超微结构的影响
3. Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells (Retraction of vol 73, pg 1549, 2008) [J] . Takada Y., Sethi G., Sung B., Molecular pharmacology. . 2016,第1期

机译：黄酮哌啶醇抑制肿瘤坏死因子诱导的活化蛋白1，c-Jun N端激酶，p38丝裂原活化蛋白激酶（MAPK），p44 / p42 MAPK和Akt的激活，抑制抗凋亡基因产物的表达并增强凋亡通过人类髓样细胞中细胞色素c的释放和胱天蛋白酶的活化（Retract of vol 73，pg 1549，2008）
4. Determining the functional role of keratin filaments in apoptosis via the PI3K/Akt signaling pathway using LTQ Orbitrap MS/MS analysis [C] . Nancy Fernandes, Nicole Morin Jaskiewicz, David H. Townson, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：使用LTQ orbitrap MS / MS分析确定通过PI3K / AKT信号通路凋亡中角蛋白长丝在细胞凋亡中的功能作用
5. The effects of mechanical forces on alveolar epithelial cells: Keratin intermediate filament network structure, phosphorylation, dynamics and mechanical properties [D] . Sivaramakrishnan, Sivaraj 2006

机译：机械力对肺泡上皮细胞的影响：角蛋白中间丝网络结构，磷酸化，动力学和机械性能
6. Re: Takada Y Sethi G Sung B and Aggarwal BB (2008) Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1 c-Jun N-terminal kinase p38 mitogen-activated protein kinase (MAPK) p44/p42 MAPK and Akt inhibits expression of antiapoptotic gene products and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells Mol Pharmacol May 2008 73:1549–1557; doi:10.1124/mol.107.041350 [O] . -1

机译：回复：Takada YSethi GSung B和Aggarwal BB（2008）黄酮哌啶醇可抑制肿瘤坏死因子诱导的活化蛋白1c-Jun N端激酶p38丝裂原活化蛋白激酶（MAPK）p44活化/ p42 MAPK和Akt可以抑制抗凋亡基因产物的表达并通过细胞色素c释放和胱天蛋白酶在人骨髓细胞中的活化来增强细胞凋亡Mol Pharmacol2008年5月73：1549-1557； doi：10.1124 / mol.107.041350
7. Ligation of β4 integrins activates PKB/Akt and ERK1/2 by distinct pathways—relevance of the keratin filament [O] . Kippenberger Stefan, Hofmann Matthias, Zöller Nadja, 2010

机译：β4整合素的连接通过不同的途径（角蛋白丝的相关性）激活PKB / Akt和ERK1 / 2
8. Analysis of Keratin Filament Assembly/Disassembly and Structure Following Modification by Sulfur Mustard Analogs [R] . Hess, J. F. , Fitzgerald, P. G. , Voss, J. C. 2005

机译：硫芥类似物改性后角蛋白纤维组装/拆卸与结构分析

Activation of PKB/Akt and p44/42 by mechanical stretch utilizes desmosomal structures and the keratin filament

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