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Transport of Nitric Oxide by Perfluorocarbon Emulsion

机译：通过全氟化碳乳液运输一氧化氮

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Perfluorocarbon (PFC) emulsions can transport and release various gases based on concentration gradients. The objective of this study was to determine the possibility of carrying and delivering exogenous nitric oxide (NO) into the circulation by simply loading PFC emulsion with NO prior infusion. PFC was equilibrated with room air (PFC) or 300 ppm NO (PFC-NO) at atmospheric pressure. Isotonic saline solution was used as a volume control (Saline). PFC and PFC-NO were infused at a dose of 3.5 mL/kg in the hamster window chamber model. Blood chemistry, and systemic and microvascular hemodynamic response were measured. Infusion of PFC preloaded with NO reduced blood pressure, induced microvascular vasodilation and increased capillary perfusion; although these changes lasted less than 30 min post infusion. On the other hand, infusion of PFC (without NO) produced vasoconstriction; however, the vasoconstriction was followed by vasodilatation at 30 min post infusion. Plasma nitrite and nitrate increased 15 min after infusion of NO preloaded PFC compared with PFC, 60 min after infusion nitrite and nitrate were not different, and 90 min after infusion plasma S-nitrosothiols increased in both groups. Infusion of NO preloaded PFC resulted in acute vascular relaxation, where as infusion of PFC (without NO) produced vasoconstriction, potentially due to NO sequestration by the PFC micelles. The late effects of PFC infusion are due to NO redistribution and plasma S-nitrosothiols. Gas solubility in PFC can provide a tool to modulate plasma vasoactive NO forms availability and improve microcirculatory function and promote increased blood flow.
机译：全氟化碳（PFC）乳液可以根据浓度梯度传输和释放各种气体。这项研究的目的是通过在输注前简单地在PFC乳液中加入NO来确定将外源性一氧化氮（NO）携带和递送到循环中的可能性。在大气压下，用室内空气（PFC）或300 ppm NO（PFC-NO）平衡PFC。等渗盐溶液用作体积对照（盐水）。在仓鼠窗室模型中，以3.5 mL / kg的剂量注入PFC和PFC-NO。测量血液化学，全身和微血管的血流动力学反应。预先充满NO的PFC输注可降低血压，诱导微血管血管舒张并增加毛细血管灌注;尽管这些变化在输注后持续不到30分钟。另一方面，输注PFC（不含NO）会引起血管收缩;但是，在输注后30分钟，血管收缩后进行血管扩张。与PFC相比，NO预加载PFC后15分钟血浆亚硝酸盐和硝酸盐增加，亚硝酸盐和硝酸盐输注60分钟后两组无明显差异，输注血浆S-亚硝基硫醇增加90分钟。灌注NO预载的PFC会导致急性血管松弛，而灌注PFC（不含NO）会产生血管收缩，这可能是由于PFC胶束对NO的螯合所致。 PFC输注的后期影响归因于NO重新分配和血浆S-亚硝基硫醇。 PFC中的气体溶解度可提供调节血浆血管活性NO形态有效性的工具，并改善微循环功能并促进血流量增加。

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