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首页> 外文期刊>Journal of endometriosis. >Abnormal pathways in endometriosis in relation to progesterone resistance: a review
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Abnormal pathways in endometriosis in relation to progesterone resistance: a review

机译：子宫内膜异位异常的异常途径与孕酮抗性有关：综述

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Introduction: Endometriosis is an estrogen-dependent disorder, and recent studies suggest that progesterone resistance may contribute to the development and pathophysiology of the disorder. Based on this, identification of genetic and molecular perturbations in the endometrium of women with endometriosis is an important step towards understanding the pathogenesis of the disease, and the development of novel treatment and diagnostic strategies.Methods: A systematic literature search in PubMed and Embase was performed, and 118 articles were identified for further screening. Two reviewers performed article screening independently using Covidence, and 16 studies fulfilled the inclusion criteria. The Newcastle-Ottawa Scale was used to assess the quality of these studies. Results: This review presents data from eutopic endometrial biopsies from women with and without endometriosis. Several biomarkers related to a downregulated progesterone response were identified and discussed in detail.Conclusions: Our review demonstrates significant results concerning the biomarkers investigated, which may substantiate the theory of progesterone resistance in women with endometriosis. However, further research is necessary to determine their specific role and relevance.
机译：介绍：子宫内膜异位症是一种雌激素依赖性疾病，最近的研究表明，孕酮的抗性可能导致这种疾病的发育和病理生理学。在此基础上，鉴定子宫内膜异位症的妇女子宫内膜中遗传和分子扰动是了解疾病发病机制的重要一步，以及新的治疗和诊断策略的发展。方法：在PubMed和Embase中进行系统的文献搜索进行，并鉴定出118篇文章进行进一步筛选。两位审稿人通过Covidence独立进行文章筛查，16项研究符合纳入标准。纽卡斯尔 - 渥太华规模用于评估这些研究的质量。结果：本评价列出了来自患有和没有子宫内膜异位症的女性的抑力子宫内膜活检数据。鉴定并详细讨论了与下调的孕酮响应有关的几种生物标志物。结论：我们的审查证明了有关所研究的生物标志物的显着成果，这可能证实了子宫内膜异位症的妇女孕酮抗性理论。然而，需要进一步研究以确定其特定的作用和相关性。

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