Retinoid metabolism in endometriosis

Yi?it ?akiro?lu; Rafael Confino; Mary Ellen Pavone

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Retinoid metabolism in endometriosis

机译：子宫内膜异位症的类视黄醇代谢

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Endometriosis is an estrogen-dependent disease in which progesterone resistance and inflammation have been found to be major mechanisms responsible for its development and progression. When compared to eutopic endometrium, key molecules have been found to be differentially expressed, which contribute to these mechanisms. One pathway that is aberrant in endometriotic tissue when compared to eutopic endometrium is the retinoic acid signaling pathway. This review focuses on the role of the retinoid signaling pathway in endometriosis and summarizes evidence that supports the use of retinoid compounds for the stimulation of pro-apoptotic activity in these cells.

机译：子宫内膜异位症是一种雌激素依赖性疾病，其中已发现孕酮的抗性和炎症是其开发和进展的主要机制。与抑力子宫内膜相比，已经发现关键分子差异表达，这有助于这些机制。与子宫内膜的子宫内膜组织中异常的一种途径是视黄酸信号通路。本综述重点介绍了类内宫源性症的类视黄醇信号传导途径的作用，并总结了支持使用类视黄醇化合物来刺激这些细胞中凋亡活性的证据。

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来源
《Journal of endometriosis.》 |2017年第4期|共7页
作者
Yi?it ?akiro?lu; Rafael Confino; Mary Ellen Pavone;
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作者单位

Department of Obstetrics and Gynecology School of Medicine Kocaeli University Kocaeli - Turkey;

Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine;

Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine;

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原文格式 PDF
正文语种 eng
中图分类妇产科学;
关键词
Apoptosis; Endometriosis; Endometrium; Retinoid metabolism; Retinoid signaling;

机译：细胞凋亡;子宫内膜异位症;子宫内膜;类视黄醇代谢;类视网膜信号传导;

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专利

1. Retinoid metabolism in endometriosis [J] . Yi?it ?akiro?lu, Rafael Confino, Mary Ellen Pavone Journal of endometriosis. . 2017,第4期

机译：子宫内膜异位症的类视黄醇代谢
2. Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action† [J] . Mary Ellen Pavone, Matthew Dyson, Scott Reirstad, Human Reproduction . 2011,第8期

机译：子宫内膜异位症的分子模式与类维生素A摄取，代谢和作用的降低相一致†
3. Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases [J] . Napoli Joseph L. Pharmacology and Therapeutics: The Journal of the International Encyclopedia of Pharmacology and Therapeutics . 2017,第期

机译：细胞类视黄醇结合蛋白，CRBP，Crabp，Fabp5：对类视黄醇代谢，功能和相关疾病的影响
4. Human metabolism of AM6-36, a retinoid X receptor-alpha ligand [C] . Lian Chen, Martin Conda-Sheridan, Mark Cushman, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：AM6-36的人代谢，一种类化醇X受体-α配体
5. Role of cellular retinaldehyde-binding protein and interphotoreceptor retinoid-binding protein in retinoid transport and metabolism in the mammalian retina. [D] . Carlson, Anne. 1994

机译：细胞视黄醛结合蛋白和感光素类视黄醇结合蛋白在哺乳动物视网膜中类视色素运输和代谢中的作用。
6. Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake metabolism and action [O] . Mary Ellen Pavone, Matthew Dyson, Scott Reirstad, -1

机译：子宫内膜异位症表达与减少类维生素A摄取代谢和作用一致的分子模式
7. Retinoid metabolism and functions mediated by retinoid binding-proteins [O] . Joseph L. Napoli, Hong Sik Yoo 2020

机译：类视黄醇代谢和由类视网膜结合蛋白介导的功能
8. Retinoids and Retinoid Metabolism in Breast Cancer [R] . Paik, J. , Swisshelm, K. 2000

机译：乳腺癌中维甲酸和类视黄醇代谢

Retinoid metabolism in endometriosis

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