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首页> 外文期刊>Journal of developmental origins of health and disease >Simple health indicators to evaluate influence of early life gluco-psychosocial factors on self-reported health in later life
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Simple health indicators to evaluate influence of early life gluco-psychosocial factors on self-reported health in later life

机译：简单的健康指标，评估早期生活血糖心理社会因素对自我报告的健康的影响

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Background: A myriad of different early life exposures to gly-cemic and psychosocial factors have been shown to be associated with long-term health. Usually the relationships between these factors and long-term health have been studied separately. However, it remains to be determined how the accumulation of different risk factors can alter long-term health. We aimed to explore the associations between gluco-psychosocial axis (GPA) score, which was based on maternal body mass index (BMI) in late pregnancy, offspring BMI at the age of 7, and childhood socioeconomic status (SES) on later life self-reported health, which was used as a surrogate marker of the ageing process. Methods: We investigated 765 men and 891 women (mean age = 61.5 years, standard deviation = 2.9). The information of maternal BMI during late pregnancy, offspring BMI at the age of 7 years, and childhood SES was based on the hospital birth records and child welfare and school health care records. The early GPA score was calculated as a sum of maternal BMI (normal weight <25 kg/m~2 = 0, overweight 25 - 29.9 kg/ m~2 =1, obese ≥30kg/m~2 =2), offspring BMI (underweight <5 percentile = 1, normal weight 5- <85 percentile = 0, overweight 85 - 94.9 percentile = 1, obese ≥95 percentile = 2), and SES (high = 0, moderate = 1, low =2) categories. GPA was divided into tertiles (low, average, high (worse)). Participant's self-reported health was based on a question from the SF-36, where people were asked to rate their general health (excellent, very good, good, fair, poor). Generalized ordered logit models were applied to investigate the association between the GPA tertiles and self-reported health tertiles (good, fair, poor). Analyses were adjusted for age. Results: In men, a low GPA score had a significantly greater probability to be identified with good health compared to the men with average (mean difference = 11.7 percentage point (pp), 95% CI 2.9-20.5, p = 0.009) or high GPA score (mean difference = 19.0 pp, 95% CI 7.6-30.5, p = 0.001). Among women, low GPA was also associated with greater probability to be identified with good health compared to the average GPA group, however, the between the group difference was only borderline significant (mean difference = 8.1 pp, 95% CI -0.8-17.0, p = 0.075). Conclusions: A favorable combined score based on early life gluco-psychosocial factors is associated with better self-reported health in later life. This association is stronger among men than in women.
机译：背景：对甘露和心理社会因素的不同早期生命曝光的无数已被证明与长期健康有关。通常，这些因素与长期健康之间的关系已经分开研究。但是，仍有待确定不同风险因素的积累可以改变长期健康。我们旨在探讨葡萄糖心理社会轴（GPA）得分的协会，基于妊娠晚期母体体重指数（BMI），在7岁时后代BMI，以及幼儿社会经济地位（SES）后世生命 - 被用作老化过程的替代标志物。方法：我们调查了765名男性和891名女性（平均年龄= 61.5岁，标准差= 2.9）。妊娠晚期母体BMI的信息，7岁时的后代BMI，儿童SES是基于医院出生记录和儿童福利和学校卫生记录。早期的GPA评分被计算为母体BMI的总和（正常重<25kg / m〜2 = 0，超重25-29.9kg / m〜2 = 1，肥胖≥30kg/ m〜2 = 2），后代BMI （不重量级<5个百分位= 1，正常重量5- <85百分位数= 0，超重85-94.9百分位数= 1，肥胖≥95个百分位= 2），SES（高= 0，中等= 1，低= 2）分类。 GPA分为泰特物（低，平均，高（更差））。参与者的自我报告的健康是基于SF-36的问题，人们被要求评估其一般健康状况（优秀，非常好，良好，公平，穷人）。广义有序的Logit模型用于调查GPA Tertiles与自我报告的健康状况（良好，公平，穷人）之间的关联。调整分析是为了年龄调整。结果：在男性，与平均男性相比，低GPA评分具有良好健康的概率显着更大（平均差异= 11.7个百分点（PP），95％CI 2.9-20.5，P = 0.009）或高GPA得分（平均差异= 19.0 pp，95％CI 7.6-30.5，p = 0.001）。在女性中，与平均GPA组相比，低GPA也与良好健康鉴定的更大概率相关，然而，基团差异只有临界显着（平均差异= 8.1pp，95％CI -0.8-17.0， P = 0.075）。结论：基于早期生命的良好的综合分数与后期生活中更好的自我报告的健康有关。这种协会在男性中比女性更强大。

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