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首页> 外文期刊>Journal of developmental origins of health and disease >The hefty fetal phenotype hypothesis revisited: high birth weight, type 2 diabetes and gestational diabetes in a Saskatchewan cohort of First Nations and non-First Nations women
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The hefty fetal phenotype hypothesis revisited: high birth weight, type 2 diabetes and gestational diabetes in a Saskatchewan cohort of First Nations and non-First Nations women

机译：重新出生的胎儿表型假设：高出生体重，2型糖尿病和胎儿糖尿病，萨斯喀彻温省第一国家和非全国妇女

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Although low birth weight (LBW) increases the risk for type 2 diabetes (T2DM), the relationship between high birth weight (HBW) and T2DM is less definitive and largely confined to North American Indigenous populations. We re-examined the relationship between LBW ( 4000 g) and both T2DM and gestational diabetes (GDM) among First Nations and non-First Nations women in Saskatchewan. We analyzed new data for female subjects from a 2001 case-control study that led to our hefty fetal phenotype hypothesis. Using survival analysis techniques and a validated algorithm for identifying diabetes in health care administrative data, we followed a 1950–1984 birth cohort of 2003 women until March 31, 2013. Cox regression analysis determined the time to occurrence of first episode of GDM and diagnosis of T2DM by birth weight and ethnicity. First Nations women with HBW demonstrated a greater risk for developing both T2DM [hazard ratios (HR) 1.568; 95% confidence interval (CI) 1.188, 2.069] and GDM (HR 1.468; 95% CI 1.016, 2.121) than those with normal birth weight (NBW). Non-First Nations women with LBW had a greater risk of developing GDM than those with NBW (HR 1.585; 95% CI 1.001, 2.512). HBW is a risk factor for GDM and T2DM among First Nations women. This is likely due to exposure of these women to their own mothers’ diabetic pregnancies or gestational impaired glucose tolerance. This inter-generational amplification of T2DM risk mediated through prenatal exposures appears to play a substantial role in the epidemic of T2DM among First Nations peoples.
机译：虽然低出生体重（LBW）增加了2型糖尿病（T2DM）的风险，但高出生体重（HBW）和T2DM之间的关系不太明确，主要限于北美土着人群。我们重新审查了萨斯喀彻温省的第一个国家和非第一国家妇女之间的LBW（4000克）和T2DM和妊娠期糖尿病（GDM）之间的关系。我们从2001年案例对照研究中分析了女性受试者的新数据，导致我们的胎儿表型假设。利用生存分析技术和验证算法识别医疗保健行政数据中的糖尿病，我们遵循了2003年3月31日的1950 - 1984年的妇女的生育队列，直到2013年3月31日。Cox回归分析确定了对GDM和诊断发作的发生时间以出生体重和种族为t2dm。患有HBW的第一个国家妇女展示了发展T2DM [危险比（HR）1.568; 95％置信区间（CI）1.188,2.069]和GDM（HR 1.468; 95％CI 1.016,2.121）比具有正常出生体重（NBW）的人。具有LBW的非First Nations妇女的风险更大的发展GDM而不是NBW（HR 1.585; 95％CI 1.001,2.512）。 HBW是一个妇女GDM和T2DM的危险因素。这可能是由于这些女性暴露于自己的母亲的糖尿病怀孕或妊娠期葡萄糖耐受性。这种通过产前暴露介导的T2DM风险的世代跨性风险似乎在第一个国家人民之间的T2DM流行病中发挥了重要作用。

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