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首页> 外文期刊>Advances in anatomy embryology and cell biology. >Genetic control of neuronal migrations in human cortical development.
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Genetic control of neuronal migrations in human cortical development.

机译:人类皮层发育中神经元迁移的遗传控制。

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The early steps in corticogenesis are decisive for the correct unfolding of neurogenesis, neuronal migration and differentiation under tight genetic control. In this monograph, we outline the main events in human preplate formation, the gradual transformation of the preplate into the cortical plate, and the establishment of the transient compartments of the foetal cortical wall. The main neuronal populations of the embryonic and fetal cortex are presented according to their timetable of appearance and the expression of developmentally relevant gene products, with the main focus on members of the Reelin-Dab1 signalling pathway, LIS1 and Doublecortin, all of which are crucial for cortical migration. The often significant developmental differences between the lissencephalic rodent brain, which has become the prevailing model of corticogenesis, and the highly differentiated, gyrated human brain are pointed out and discussed.
机译:在严格的遗传控制下,皮质发生的早期步骤对于神经发生,神经元迁移和分化的正确展开具有决定性作用。在本专着中,我们概述了人类前板形成中的主要事件,前板逐渐转变为皮质板以及胎儿皮质壁的短暂隔室的建立。根据出现时间表和发育相关基因产物的表达,显示了胚胎和胎儿皮质的主要神经元种群,主要集中在Reelin-Dab1信号通路,LIS1和Doublecortin的成员上,这些都是至关重要的用于皮层迁移。指出并讨论了已成为皮质发生流行模型的小脑啮齿动物大脑与高分化,回旋的人类大脑之间经常存在的显着差异。

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