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首页> 外文期刊>Journal of Experimental Botany >Rhodanese domain-containing sulfurtransferases: multifaceted proteins involved in sulfur trafficking in plants
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Rhodanese domain-containing sulfurtransferases: multifaceted proteins involved in sulfur trafficking in plants

机译：含葡聚糖含硫磺转移酶：涉及血管贩运植物的多方素蛋白

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摘要

Sulfur is an essential element for the growth and development of plants, which synthesize cysteine and methionine from the reductive assimilation of sulfate. Besides its incorporation into proteins, cysteine is the building block for the biosynthesis of numerous sulfur-containing molecules and cofactors. The required sulfur atoms are extracted either directly from cysteine by cysteine desulfurases or indirectly after its catabolic transformation to 3-mercaptopyruvate, a substrate for sulfurtransferases (STRs). Both enzymes are transiently persulfidated in their reaction cycle, i.e. the abstracted sulfur atom is bound to a reactive cysteine residue in the form of a persulfide group. Trans-persulfidation reactions occur when sulfur atoms are transferred to nucleophilic acceptors such as glutathione, proteins, or small metabolites. STRs form a ubiquitous, multigenic protein family. They are characterized by the presence of at least one rhodanese homology domain (Rhd), which usually contains the catalytic, persulfidated cysteine. In this review, we focus on Arabidopsis STRs, presenting the sequence characteristics of all family members as well as their biochemical and structural features. The physiological functions of particular STRs in the biosynthesis of molybdenum cofactor, thio-modification of cytosolic tRNAs, arsenate tolerance, cysteine catabolism, and hydrogen sulfide formation are also discussed.
机译：硫是植物生长和发育的基本要素，其将半胱氨酸和蛋氨酸合成硫酸盐的还原同化。除了将其掺入蛋白质外，半胱氨酸是用于含硫含硫分子和辅因子的生物合成的结构块。所需的硫原子通过半胱氨酸脱硫或间接地从半胱氨酸中萃取，或间接在其分解代谢转化为3-巯基吡喃酸酯后，用于硫磺转移酶（strs）的基材。两种酶在反应循环中瞬时过硫化，即，抽象的硫原子以过硫化物基团的形式与反应性半胱氨酸残基结合。当硫原子转移到亲肠道受体（例如谷胱甘肽，蛋白质或小代谢物）中时，发生反式过硫化反应。 strs形成普遍存在的多粒蛋白质家庭。它们的特征在于存在至少一种罗丹语同源结构域（RHD），其通常含有催化，过硫化半胱氨酸。在这篇综述中，我们专注于拟南芥strs，呈现所有家庭成员的序列特征以及它们的生化和结构特征。还讨论了钼克接族的生物合成中的特定strs的生理功能，细胞溶质TrNA的硫代改性，砷酸盐耐受性，半胱氨酸分解代谢和硫化氢形成。

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