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首页> 外文期刊>Biotechnology Advances: An International Review Journal >From short peptides to nanofibers to macromolecular assemblies in biomedicine
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From short peptides to nanofibers to macromolecular assemblies in biomedicine

机译：从短肽到纳米纤维再到生物医学中的大分子组装

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In the last few years, a variety of self-assembling short peptides that consist exclusively of simple amino acids have been designed and modified. These peptides exhibit self-assembling dynamic behaviors. At the molecular structural level, they form alpha-helical, beta-sheet and beta-hairpins structures in water. These structures further undergo spontaneous assembly to form nanofibers which aggregate into supramolecular scaffolds that entrap large volumes of water. Furthermore, nanostructures and supramolecular structures that self-organized from these short peptides also have a broad spectrum of biotechnological applications. They are useful as biological materials for 2D and 3D tissue cell cultures, regenerative and reparative medicine, tissue engineering as well as injectable drug delivery matrices that gel in situ. We have endeavored to do a comprehensive review of short peptides that form nanofibrous hydrogels. In particular, we have focused on recent advances in peptide assembly motifs and applications
机译：在最近几年中，已经设计和修饰了多种仅由简单氨基酸组成的自组装短肽。这些肽表现出自组装的动力学行为。在分子结构水平上，它们在水中形成α-螺旋，β-折叠和β-发夹结构。这些结构进一步自发组装以形成纳米纤维，这些纳米纤维聚集成包裹大量水的超分子支架。此外，由这些短肽自组织的纳米结构和超分子结构也具有广泛的生物技术应用范围。它们可用作2D和3D组织细胞培养，再生和修复医学，组织工程以及可原位凝胶化的可注射药物输送基质的生物材料。我们致力于对形成纳米纤维水凝胶的短肽进行全面综述。特别是，我们专注于肽装配基序和应用的最新进展

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