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Shining light on nanotechnology to help repair and regeneration

机译:照亮纳米技术以帮助修复和再生

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摘要

Phototherapy can be used in two completely different but complementary therapeutic applications. While low level laser (or light) therapy (LLLT) uses red or near-infrared light alone to reduce inflammation, pain and stimulate tissue repair and regeneration, photodynamic therapy (PDT) uses the combination of light plus non-toxic dyes (called photosensitizers) to produce reactive oxygen species that can kill infectious microorganisms and cancer cells or destroy unwanted tissue (neo-vascularization in the choroid, atherosclerotic plaques in the arteries). The recent development of nanotechnology applied to medicine (nanomedicine) has opened a new front of advancement in the field of phototherapy and has provided hope for the development of nanoscale drug delivery platforms for effective killing of pathological cells and to promote repair and regeneration. Despite the well-known beneficial effects of phototherapy and nanomaterials in producing the killing of unwanted cells and promoting repair and regeneration, there are few reports that combine all three elements i.e. phototherapy, nanotechnology and, tissue repair and regeneration. However, these areas in all possible binary combinations have been addressed by many workers. The present review aims at highlighting the combined multi-model applications of phototherapy, nanotechnology and, reparative and regeneration medicine and outlines current strategies, future applications and limitations of nanoscale-assisted phototherapy for the management of cancers, microbial infections and other diseases, and to promote tissue repair and regeneration
机译:光疗可以用于两种完全不同但互补的治疗应用中。低水平激光(或光)疗法(LLLT)仅使用红色或近红外光来减轻炎症,疼痛并刺激组织修复和再生,而光动力疗法(PDT)则将光与无毒染料(称为光敏剂)结合使用)产生活性氧,可以杀死感染性微生物和癌细胞或破坏不需要的组织(脉络膜中的新血管形成,动脉中的动脉粥样硬化斑块)。应用于医学(纳米医学)的纳米技术的最新发展打开了光疗领域的新前沿,并为开发纳米级药物递送平台提供了希望,该平台可有效杀死病理细胞并促进修复和再生。尽管光疗和纳米材料在杀死不需要的细胞并促进修复和再生方面具有众所周知的有益作用,但很少有报道将光疗,纳米技术以及组织修复和再生这三个要素结合在一起。但是,许多工人已经解决了所有可能的二进制组合中的这些区域。本综述旨在强调光疗,纳米技术以及修复和再生医学的多种模式组合应用,并概述了纳米级光疗在癌症,微生物感染和其他疾病管理中的当前策略,未来应用和局限性,以及促进组织修复和再生

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