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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Advances in repairing the degenerate retina by rod photoreceptor transplantation
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Advances in repairing the degenerate retina by rod photoreceptor transplantation

机译：棒状感光细胞移植修复变性视网膜的研究进展

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Despite very different aetiologies, age-related macular degeneration (AMD) and most inherited retinal disorders culminate in the same final common pathway, loss of the light-sensitive photoreceptors. There are few clinical treatments and none can reverse the loss of vision. Photoreceptor replacement by transplantation is proposed as a broad treatment strategy applicable to all degenerations. The past decade has seen a number of landmark achievements in this field, which together provide strong justification for continuing investigation into photoreceptor replacement strategies. These include proof of principle for restoring vision by rod-photoreceptor transplantation in mice with congenital stationary night blindness and advances in stem cell biology, which have led to the generation of complete optic structures in vitro from embryonic stem cells. The latter represents enormous potential for generating suitable and renewable donor cells with which to achieve the former. However, there are still challenges presented by the degenerating recipient retinal environment that must be addressed as we move to translating these technologies towards clinical application.
机译：尽管病因差异很大，但年龄相关性黄斑变性（AMD）和大多数遗传性视网膜疾病最终以相同的最终共同途径达到终点，即光敏感光细胞的丧失。临床治疗很少，没有一种可以逆转视力丧失。提出通过移植替代感光体作为适用于所有变性的广泛治疗策略。在过去的十年中，该领域取得了许多里程碑式的成就，这些共同为继续研究感光器替代策略提供了有力的依据。这些包括通过先天性静止性夜盲症小鼠的杆状光感受器移植恢复视力的原理证明，以及干细胞生物学的进步，这导致了胚胎干细胞在体外产生完整的光学结构。后者代表了产生合适的和可再生的供体细胞以实现前者的巨大潜力。然而，当我们将这些技术转化为临床应用时，退化的受体视网膜环境仍然存在挑战，必须解决这些挑战。

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