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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Advances in algal drug research with emphasis on enzyme inhibitors
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Advances in algal drug research with emphasis on enzyme inhibitors

机译：藻类药物研究的新进展，重点是酶抑制剂

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Enzyme inhibitors are now included in all kinds of drugs essential to treat most of the human diseases including communicable, metabolic, cardiovascular, neurological diseases and cancer. Numerous marine algae have been reported to be a potential source of novel enzyme inhibitors with various pharmaceutical values. Thus, the purpose of this review is to brief the enzyme inhibitors from marine algae of therapeutic potential to treat common diseases. As per our knowledge this is the first review for the potential enzyme inhibitors from marine origin. This review contains 86 algal enzyme inhibitors reported during 1989-2013 and commercial enzyme inhibitors available in the market. Compounds in the review are grouped according to the disease conditions in which they are involved; diabetes, obesity, dementia, inflammation, melanogenesis, AIDS, hypertension and other viral diseases. The structure-activity relationship of most of the compounds are also discussed. In addition, the drug likeness properties of algal inhibitors were evaluated using Lipinski's 'Rule of Five'. (c) 2014 Elsevier Inc. All rights reserved.
机译：现在，酶抑制剂已包含在治疗大多数人类疾病（包括传染性，代谢性，心血管性，神经性疾病和癌症）中必不可少的各种药物中。据报道，许多海藻是具有各种药物价值的新型酶抑制剂的潜在来源。因此，本综述的目的是简要介绍海藻中的酶抑制剂，以治疗常见疾病。据我们所知，这是对来自海洋的潜在酶抑制剂的首次综述。这篇综述包含了1989-2013年间报道的86种藻类酶抑制剂和市场上可买到的商业酶抑制剂。综述中的化合物根据其所涉及的疾病状况进行分组;糖尿病，肥胖，痴呆，炎症，黑色素生成，艾滋病，高血压和其他病毒性疾病。还讨论了大多数化合物的结构活性关系。此外，使用Lipinski的“五则规则”评估了藻类抑制剂的药物相似性。 （c）2014 Elsevier Inc.保留所有权利。

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