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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Biomaterials surfaces capable of resisting fungal attachment and biofilm formation.
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Biomaterials surfaces capable of resisting fungal attachment and biofilm formation.

机译：能够抵抗真菌附着和生物膜形成的生物材料表面。

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Microbial attachment onto biomedical devices and implants leads to biofilm formation and infection; such biofilms can be bacterial, fungal, or mixed. In the past 15 years, there has been an increasing research effort into antimicrobial surfaces but the great majority of these publications present research on bacteria, with some reports also testing resistance to fungi. Very few studies have focused exclusively on antifungal surfaces. However, with increasing recognition of the importance of fungal infections to human health, particularly related to infections at biomaterials, it would seem that the interest in antifungal surfaces is disproportionately low. In studies of both bacteria and fungi, fungi tend to be the minor focus with hypothesized antibacterial mechanisms of action often generalized to also explain the antifungal effect. Yet bacteria and fungi represent two Distinct biological Domains and possess substantially different cellular physiology and structure. Thus it is questionable whether these generalizations are valid. Here we review the scientific literature focusing on surface coatings prepared with antifungal agents covalently attached to the biomaterial surface. We present a critical analysis of generalizations and their evidence. This review should be of interest to researchers of "antimicrobial" surfaces by addressing specific issues that are key to designing and understanding antifungal biomaterials surfaces and their putative mechanisms of action.
机译：微生物附着在生物医学设备和植入物上会导致生物膜形成和感染;这样的生物膜可以是细菌的，真菌的或混合的。在过去的15年中，对抗菌表面的研究工作日渐增多，但是这些出版物中的绝大多数都对细菌进行了研究，有些报告还测试了对真菌的抗药性。很少有研究专门针对抗真菌表面。然而，随着人们日益认识到真菌感染对人类健康的重要性，尤其是与生物材料感染有关的重要性，人们似乎对抗真菌表面的兴趣不成比例。在细菌和真菌的研究中，真菌往往是次要的焦点，其假设的抗菌作用机制通常可以概括为也解释其抗真菌作用。然而，细菌和真菌代表了两个不同的生物学领域，并具有实质上不同的细胞生理学和结构。因此，这些概括是否有效值得怀疑。在这里，我们回顾有关以共价附着于生物材料表面的抗真菌剂制备的表面涂层的科学文献。我们对归纳及其证据进行了批判性分析。对于“抗微生物”表面的研究人员来说，该评论应引起关注，方法是解决特定问题，这些问题对于设计和理解抗真菌生物材料表面及其推定的作用机理至关重要。

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