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Bionanoconjugation for Proteomics applications - An overview

机译：蛋白质组学应用中的Bionanoconjugation-概述

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Formed as an interdisciplinary domain on the basis of Human Genome Project, Proteomics aims at the large-scale study of proteins. The enthusiasm that resulted from obtaining the complete human genetic information has, however, been chastened by the realization that this information contributes little to the comprehension and knowledge of the expressed proteins. In the wake of this realization, the Human Proteome Project (HUPO) was founded, which is a global, collaborative initiative, aiming at the complete characterization of the proteins of all protein-coding genes. Nonetheless, the rapid detection of these molecules in complex biological samples under conditions considered to be of clinical relevance is extremely difficult, requiring the development of very sensitive, robust, reproducible and high throughput platforms. Nanoproteomics has emerged as a feasible, promising option, offering short assay times, low sample consumption, ultralow detection and high throughput capacity. Additionally, the successful synthesis of biomolecules and nanoparticle hybrids yields systems which often exhibit new or improved features. Herein, we overview the recent advances in bioconjugation at the nanolevel and, specifically, their application in Proteomics, discussing not only the merits and prospects of Proteomics, but also present day limitations
机译：蛋白质组学是根据人类基因组计划建立的一个跨学科领域，旨在蛋白质的大规模研究。但是，由于获得了完整的人类遗传信息而产生的热情，使人们意识到，这些信息对表达的蛋白质的理解和知识贡献很小。意识到这一点之后，人类蛋白质组计划（HUPO）成立了，这是一项全球性的合作计划，旨在对所有蛋白质编码基因的蛋白质进行全面表征。然而，在被认为具有临床相关性的条件下，在复杂的生物样品中快速检测这些分子非常困难，需要开发非常灵敏，坚固，可重现和高通量的平台。纳米蛋白质组学已成为一种可行的，有前途的选择，提供了较短的测定时间，低样品消耗，超低检测和高通量的能力。另外，生物分子和纳米粒子杂化物的成功合成产生了通常表现出新的或改进的特征的系统。在本文中，我们概述了生物结合在纳米水平上的最新进展，尤其是它们在蛋白质组学中的应用，不仅讨论了蛋白质组学的优点和前景，而且还讨论了当今的局限性

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