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首页> 外文期刊>Journal of genetics >Genetic analysis of drug metabolizing phase-I enzymes CYP3A4 in Tibetan populations
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Genetic analysis of drug metabolizing phase-I enzymes CYP3A4 in Tibetan populations

机译：藏人群中药物代谢相酶CYP3A4的遗传分析

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摘要

The enzymatic activity of CYP3A4 results in broad interindividual variability in response to certain pharmacotherapies. The present study aimed to screen Tibetan volunteers for CYP3A4 genetic polymorphisms. Previous research has focussed on Han Chinese patients, while little is known about the genetic variation of CYP3A4 in the Tibetan populations. Here, we adopted DNA sequencing to investigate the promoter, exons and surrounding introns, and 3 (')-untranslated region of the CYP3A4 gene in 96 unrelated healthy Tibetan individuals. We identified 20 different CYP3A4 polymorphisms in the Tibetan population, including two novel variants (21824 A > G and 15580 G > C). In addition, we also determined the allele frequencies of CYP3A4*1A and CYP3A4*1H were 82.29% and 28.13%, respectively. CYP3A4*1P and *1G were relatively rare with frequencies of only 1.04% and 0.52%, respectively. Our results provide information on CYP3A4 polymorphisms in Tibetan individuals which may help to optimize pharmacotherapy effectiveness by providing personalized medicine to this ethnic group.
机译：CYP3A4的酶活性导致响应某些药物治疗的广泛的接头变异性。本研究旨在筛选西藏志愿者CYP3A4遗传多态性。以前的研究侧重于汉族患者，虽然藏人群中CYP3A4的遗传变异很少。在这里，我们采用DNA测序来研究96个无关的健康藏人中CYP3A4基因的3（'）-Unralscated区域。我们在藏人群中鉴定了20种不同的CYP3A4多态性，包括两种新型变体（21824A> G和15580g> c）。此外，我们还确定了CYP3A4 * 1A和CYP3A4 * 1H的等位基因频率分别为82.29％和28.13％。 CYP3A4 * 1P和* 1G分别比仅为1.04％和0.52％的频率相对罕见。我们的结果提供了藏人物中Cyp3a4多态性的信息，这可能通过向该族群提供个性化药物来帮助优化药物疗法效率。

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  • 来源
    《Journal of genetics》 |2017年第2期|共7页
  • 作者

    Liu Lijun; Chang Yu; Du Shuli; Shi Xugang; Yang Hua; Kang Longli; Jin Tianbo; Yuan Dongya; He Yongjun;

  • 作者单位

    Xizang Minzu Univ Key Lab Mol Genet Mech &

    Intervent Res High Altit Xianyang 712082 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Hong Hui Hosp Dept Pharm Coll Med Xian 710054 Shaanxi Peoples R China;

    Xian Tiangen Precis Med Inst Xian 710075 Shaanxi Peoples R China;

    Xian Tiangen Precis Med Inst Xian 710075 Shaanxi Peoples R China;

    Xian Tiangen Precis Med Inst Xian 710075 Shaanxi Peoples R China;

    Xizang Minzu Univ Key Lab Mol Genet Mech &

    Intervent Res High Altit Xianyang 712082 Shaanxi Peoples R China;

    Xizang Minzu Univ Key Lab Mol Genet Mech &

    Intervent Res High Altit Xianyang 712082 Shaanxi Peoples R China;

    Xizang Minzu Univ Key Lab Mol Genet Mech &

    Intervent Res High Altit Xianyang 712082 Shaanxi Peoples R China;

    Xizang Minzu Univ Key Lab Mol Genet Mech &

    Intervent Res High Altit Xianyang 712082 Shaanxi Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    CYP3A4; genetic polymorphism; genotype; phenotype; Tibetan;

    机译：CYP3A4;遗传多态性;基因型;表型;藏族;

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