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首页> 外文期刊>Journal of genetics >Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis
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Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis

机译：NFKB1A和MicroRNA的变异和动脉粥样硬化的敏感性

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Atherosclerosis (AT) is a chronic immuno-inflammatory disease characterized by inflammatory mediators and immune activation in arterial wall. Although NF-B and micro RNAs are involved in the atherosclerotic lesions, the pathogenesis of atherosclerosis is still unknown. The aim of this study was to investigate the association of atherosclerosis with NFKB1-rs28362491, NFKBIA-rs696, pre-miRNA-146a-rs2910164 and pre-miRNA-499-rs3746444 polymorphisms as well as the analysis of their single and combined effects on its susceptibility in a Turkish population. We analysed the distribution of NFKB1-94 ins/del ATTG (rs28362491), NFKBIA (rs696), pre-miR-146a (rs2910164) and pre-miR-499 (rs3746444) genetic polymorphisms using PCR-RFLP assay in 150 atherosclerotic patients and 145 healthy controls in a Turkish population. The data revealed no significant differences in the distribution of the genotype and alleles of rs28362491 ,whereas AA genotype of rs696 lead to a higher risk for atherosclerotic patients. TT genotype and T allele of pre-miR-499 rs3746444 were found to be associated with atherosclerosis risk. In addition, significant differences were found between atherosclerotic patients and control subjects, concerning pre-miR-146a rs2910164 polymorphism. The subjects carrying the GG genotype and G allele of rs2910164 were found to have an increased risk against AT. The results of combined genotype analysis, showed no notable differences between the multiple comparisons of rs28362491-rs696 whereas rs28362491-rs2910164 ins/ins/GG is associated with increased AT risk. The combined genotypes of rs28362491/rs3746444 ins/ins/TT, revealed a significant protective effect on AT. These findings indicate that genetic polymorphisms of NFKB1A rs696, pre-miR-146a rs2910164 and pre-miR-499 rs3746444 may represent novel markers of AT susceptibility.
机译：动脉粥样硬化（AT）是一种慢性免疫炎症疾病，其特征在于炎症介质和动脉壁的免疫激活。虽然NF-B和微RNA参与动脉粥样硬化病变，但动脉粥样硬化的发病机制仍然未知。本研究的目的是探讨动脉粥样硬化与NFKB1-RS28362491，NFKBIA-RS696，前miRNA-146A-RS2910164和Pre-MiRNA-499-RS3746444的多态性以及分析它们的单身和综合影响土耳其人口的易感性。我们分析了NFKB1-94 INS / DEL ATTG（RS28362491），NFKBIA（RS696），MIR-146A（RS2910164）和预先使用PCR-RFLP测定的遗传多态性在150例动脉粥样硬化患者中的遗传多态性的分布145土耳其人口的健康控制。数据显示，RS28362491的基因型和等位基因的分布没有显着差异，而AA基因型为RS696的基因型导致动脉粥样硬化患者的风险更高。发现了MIR-499 RS3746444前的TT基因型和T等位基因与动脉粥样硬化风险有关。此外，在动脉粥样硬化患者和对照对象之间发现了显着的差异，关于预先miR-146A RS2910164多态性。携带RS2910164的携带GG基因型和G等位基因的受试者患有增加的风险。组合基因型分析结果显示，在RS28362491-RS696的多个比较之间没有显着差异，而RS28362491-RS2910164 INS / INS / GG与风险增加相关。 RS28362491 / RS3746444 INS / INS / TT的合并基因型显示出对AT的显着保护作用。这些发现表明NFKB1A RS696，MIR-146A RS2910164和MIR-499 RS3746444的遗传多态性可以代表易感性的新标记。

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