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Genetics of obesity and its measures in India

机译：肥胖的遗传及其在印度的措施

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Obesity is one of the largest global health problems associated with increased morbidity and mortality mediated by its association with several other metabolic disorders. The interaction between the genes and environment plays an important role in the manifestation of obesity. Despite a high heritability (40-70%) of obesity, the search for genetic variants associated with obesity susceptibility has been a challenging task. To date, limited studies have been conducted in India, restricted to the validation of few genetic variants identified by genomewide association studies. In this critical review, we sought to examine the current knowledge of genetic basis of obesity and its measures in the Indian population. A comprehensive literature search was performed using 'PubMed', 'Medline' and 'IndMed' databases to search for citations published until 31st May 2017, using the key terms as 'Genetics' AND 'obesity' AND 'India'. We identified 48 potential studies which fulfilled the eligibility criteria. The findings indicated that FTO, MC4R, TNF-alpha, PPAR-gamma, UCP1, UCP2, LPL, LEPR, AMD1, IL6, APOE, ADIPOQ, DOK5, INSIG2, PBEF1, IL6R, Myostatin, CXCR4, HHEX, IRX3, POMC, NGN3, FOXA2, MTR, TCN and CHDH are some of the important genes studied among the Indian population. Importantly, the role of sexual dimorphism in the genetic regulation of obesity and body fat distribution was also reported in a few studies. Further, seven biological pathways have been identified that contribute to obesity pathogenesis in India. In conclusion, further exploration of pathway-based research on genetics of obesity can be useful for better understanding the pathophysiology of obesity in India.
机译：肥胖是与其与其他几种代谢障碍介导的发病率和死亡率增加的最大全球健康问题之一。基因与环境之间的相互作用在肥胖症的表现中起着重要作用。尽管有穷困性（40-70％）肥胖症，但寻找与肥胖敏感性相关的遗传变异是一项挑战性的任务。迄今为止，在印度进行了有限的研究，仅限于少数基因组合协会研究鉴定的若干遗传变异的验证。在这次批判性审查中，我们试图研究目前对印度人口遗传基础的现状及其措施。使用“PubMed”，“Medline”和“Indmed”数据库来搜索全面的文献搜索，以搜索发表的引文，直到2017年5月31日，使用关键术语为“遗传学”和“肥胖”和“印度”。我们确定了48项潜在的研究，符合资格标准。研究结果表明，FTO，MC4R，TNF-α，PPAR-Gamma，UCP1，UCP2，LPL，LEPR，AMD1，IL6，ApoE，AdipoQ，DoK5，Insig2，PBEF1，IL6R，Myostatin，CXCR4，HHEX，IRX3，POMC， NGN3，FOXA2，MTR，TCN和CHDH是印度人口中学研究的一些重要基因。重要的是，在一些研究中还报道了性别二态在肥胖和体脂分布遗传调节中的作用。此外，已经确定了七种生物途径，这有助于在印度肥胖发病。总之，对肥胖遗传遗传学研究的进一步探索可用于更好地了解印度肥胖的病理生理学。

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