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Genetics of obesity and its measures in India

机译：印度肥胖症的遗传学及其对策

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Obesity is one of the largest global health problems associated with increased morbidity and mortality mediated by its association with several other metabolic disorders. The interaction between the genes and environment plays an important role in the manifestation of obesity. Despite a high heritability (40a??70%) of obesity, the search for genetic variants associated with obesity susceptibility has been a challenging task. To date, limited studies have been conducted in India, restricted to the validation of few genetic variants identified by genomewide association studies. In this critical review, we sought to examine the current knowledge ofgenetic basis of obesity and its measures in the Indian population. A comprehensive literature search was performed using a??PubMeda??, a??Medlinea?? and a??IndMeda?? databases to search for citations published until 31st May 2017, using the key terms as a??Geneticsa?? AND a??obesitya?? AND a??Indiaa??. We identified 48 potential studies which fulfilled the eligibility criteria. The findings indicated thatFTO , MC4R, TNF-?±, PPAR-?3 , UCP1, UCP2, LPL, LEPR, AMD1, IL6, APOE, ADIPOQ, DOK5, INSIG2, PBEF1, IL6R, Myostatin, CXCR4, HHEX, IRX3, POMC, NGN3, FOXA2, MTR, TCN and CHDH are some of the important genes studied among the Indian population. Importantly, the role of sexual dimorphism in the genetic regulation of obesity and body fat distribution was also reported in a few studies. Further, seven biological pathways have been identified that contribute to obesity pathogenesis in India. In conclusion, further exploration of pathway-based research on genetics of obesity can be useful for better understanding thepathophysiology of obesity in India.
机译：肥胖是与其他几种代谢性疾病相关的疾病，与发病率和死亡率增加相关，是全球最大的健康问题之一。基因与环境之间的相互作用在肥胖的表现中起着重要的作用。尽管肥胖症的遗传性很高（40a-70％），但是寻找与肥胖症易感性相关的遗传变异仍然是一项艰巨的任务。迄今为止，在印度进行的研究有限，仅限于验证通过全基因组关联研究鉴定出的少数遗传变异。在这项重要的综述中，我们试图检查印度人肥胖的遗传基础及其措施的当前知识。使用“ PubMeda”，“ Medlinea”和“ Medlinea”进行了全面的文献检索。还有一个?? IndMeda ??数据库检索使用2017年5月31日之前发布的引文，并使用关键词“ Geneticsa”还有一个？肥胖症？和一个??印度??。我们确定了48项符合资格标准的潜在研究。结果表明FTO，MC4R，TNF-α±，PPAR-β3，UCP1，UCP2，LPL，LEPR，AMD1，IL6，APOE，ADIPOQ，DOK5，INSIG2，PBEF1，IL6R，肌生长抑制素，CXCR4，HHEX，IRX3，POMC NGN3，FOXA2，MTR，TCN和CHDH是印度人群中研究的重要基因。重要的是，一些研究还报道了性二态性在肥胖和体脂分布的遗传调控中的作用。此外，已经确定了有助于印度肥胖症发病机理的七种生物学途径。总之，进一步探索基于途径的肥胖症遗传学研究可能有助于更好地了解印度肥胖症的病理生理学。

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