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首页> 外文期刊>Journal of glaucoma >Meibomian Gland Features and Conjunctival Goblet Cell Density in Glaucomatous Patients Controlled With Prostaglandin/Timolol Fixed Combinations: A Case Control, Cross-sectional Study
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Meibomian Gland Features and Conjunctival Goblet Cell Density in Glaucomatous Patients Controlled With Prostaglandin/Timolol Fixed Combinations: A Case Control, Cross-sectional Study

机译：用前列腺素/蒂洛尔固定组合控制的青光瘤患者的睑板腺特征和结膜脚卵细胞密度：案例控制，横截面研究

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Purpose:To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs).Materials and Methods:In this cross-sectional study, 60 white patients were treated with PTFCs, 15 with latanoprost+timolol (L+T) unfixed combination, and 15 controls were enrolled. Patients underwent the Ocular Surface Disease Index questionnaire, tear film breakup time, corneal staining, Schirmer test I, and IVCM of MGs and goblet cells. The main outcome measures were: mean Meibomian acinar density (MMAD) and area (MMAA), inhomogeneity of glandular interstice (InI) and acinar wall (InAW), and GCD.Results:PTFCs were: latanoprost/timolol (LTFC, 15 eyes), travoprost/timolol (TTFC, 15), bimatoprost/timolol (BTFC, 15), and preservative-free bimatoprost/timolol (PF-BTFC, 15) fixed combinations. Mean time on therapy did not differ among treatments. IVCM documented lower GCD, MMAD, and MMAA (P0.001), and greater InI and InAW (P0.05) in glaucoma patients compared with controls. L+T showed worse values compared with PTFCs and PF-BTFC (P0.05). Preserved PTFCs showed lower MMAD, MMAA, GCD, and greater InI and InAW compared with PF-BTFC (P0.05) and controls (P0.001). Differences were not found among PTFCs. InI and InAW significantly correlated with Ocular Surface Disease Index and breakup time (P0.001), corneal staining (P0.05), and GCD (P0.001); GCD correlated with MMAD (P0.05).Conclusions:PTFCs were less toxic towards MGs and goblet cells compared with the L+T unfixed combination, with PF-BTFC presenting the most tolerated profile. These findings should be carefully considered given the role of these structures in the induction of the glaucoma-related ocular surface disease.
机译：目的：要研究，使用体内共聚焦显微镜（IVCM），睑板腺（Mg）特征和结膜脚卵细胞密度（GCD）在肺菌患者中控制，用前列腺素/蒂洛尔固定组合（PTFC）。材料和方法：在这十字架上 - 检测研究，用PTFC治疗60名白色患者，用LatanoProprost +蒂莫尔（L + T）未固定组合，注册了15个对照。患者接受了眼部表面疾病指数调查问卷，泪膜破碎时间，角膜染色，席克和脚杯细胞的IVCM。主要结果措施是：平均睑板酰基密度（MMAD）和面积（MMAA），腺间隙（INI）和缩醛壁（INAW）的不均匀性，以及GCD。结果：PTFC是：Latanoproprost / Timolol（LTFC，15只眼） ，TraveRost / Timolol（TTFC，15），Bimatoprost /蒂莫尔（BTFC，15）和无防腐Bimatoprost / Timolol（PF-BTFC，15）固定组合。治疗的平均时间在治疗中没有差异。 IVCM记录了低GCD，MMAD和MMAA（P＆LT; 0.001），与对照相比，青光眼患者中的更大的ini和InaI（P <0.05）。与PTFCS和PF-BTFC（P <0.05）相比，L + T表示更差的值。与PF-BTFC（P <0.05）和对照（P <0.001）相比，保存的PTFC显示较低的MMAD，MMAA，GCD和更大的ini和iniaAW和in.在PTFC中没有发现差异。 INI和Inaw与眼表面疾病指数和分解时间显着相关（P <0.001），角膜染色（P <0.05）和GCD（P <0.001）; GCD与MMAD相关（P <0.05）。结论：与L + T未固定的组合相比，PTFC对MGS和脚卵细胞毒性较小，PF-BTFC呈现最宽容的轮廓。应仔细考虑这些调查结果，鉴于这些结构在诱导青光眼相关的眼部疾病中的作用。

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