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首页> 外文期刊>Journal of glaucoma >Effect of Latanoprost on Choroidal Thickness
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Effect of Latanoprost on Choroidal Thickness

机译：拉坦斯洛克斯对脉络膜厚度的影响

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Purpose:The purpose of this study was to evaluate the changes in choroidal thickness during the use of latanoprost eyedrops which shift fluid to the suprachoroidal space and change choroidal perfusion.Materials and Methods:This prospective study included 34 eyes of 17 bilateral glaucoma or ocular hypertensive patients who had no previous hypotensive therapy. Each patient had both eyes treated with latanoprost. Each patient also underwent a complete ophthalmological examination and optical coherence tomography measurement. Choroidal thickness measurements by optical coherence tomography were carried out on the first visit before latanoprost use and at time intervals of 7 and 30 days of therapy.Results:The patients' mean age was 62.311 years (range, 30 to 83y). Of 17 patients, 7 were female individuals. There were no significant differences in central choroidal thicknesses at the fovea, or at each point within the horizontal nasal and temporal quadrants between visits (P0.05 for all comparisons).Conclusions:The current study showed that choroidal thickness does not change after latanoprost therapy. However, the choroidal changes of anterior part of the eye can be effected by the latanoprost therapy. Future studies investigating the anterior part of the eye and focusing on both choroidal perfusion and choroidal thickness may give additional information concerning the mechanism of action.
机译：目的：本研究的目的是评估使用Latanoprost EyeDrops期间的脉络膜厚度的变化，该吸管将流体移至Suprachoroidallapal空间并改变脉络膜灌注。材料和方法：这项前瞻性研究包括34只双侧青光眼或眼部高血压的眼睛没有先前的低血压治疗的患者。每位患者均用Latanoprost治疗双眼。每位患者还经历了完整的眼科检查和光学相干断层扫描测量。通过光学相干断层扫描的脉络膜厚度测量是在拉坦斯普洛克斯特前的第一次访问中进行，并在治疗的时间间隔为7和30天。结果：患者的平均年龄为62.311岁（范围，30至83Y）。 17例患者，7例是女性个人。在FOVEA的中央脉络膜厚度或访问之间的每个点在访问之间的各个点（P <0.05进行所有比较）中没有显着差异。结论：目前的研究表明，Latanoprost治疗后脉络膜厚度不会改变。 。然而，眼睛前部的脉络膜变化可以通过拉巴斯隆治疗来实现。未来研究调查眼睛的前部和专注于脉络膜灌注和脉络膜厚度可以提供有关作用机制的额外信息。

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