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首页> 外文期刊>Journal of glaucoma >A Sectoral Analysis of Vessel Density Measurements in Perimetrically Intact Regions of Glaucomatous Eyes: An Optical Coherence Tomography Angiography Study
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A Sectoral Analysis of Vessel Density Measurements in Perimetrically Intact Regions of Glaucomatous Eyes: An Optical Coherence Tomography Angiography Study

机译：血糖瘤眼周围完整区域的血管密度测量的部门分析：光学相干断层血管造影研究

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Purpose:To study sectoral vessel density (VD) and structural alterations in the peripapillary and parafoveal hemiretina corresponding to perimetrically intact regions of glaucomatous eyes with hemifield defects and to compare these with healthy eyes using optical coherence tomography.Methods:This cross-sectional study included 37 eyes with open-angle glaucoma having visual fields defects restricted to 1 hemifield and 45 age-matched controls. Peripapillary VD and retinal nerve fiber layer (RNFL) thickness were measured in 8 sectors. Parafoveal VD and ganglion cell complex thickness were measured in the superior and inferior hemispheres of the macula. These parameters were compared between the intact hemiretinae of glaucomatous eyes and corresponding sectors of healthy eyes using the t test.Results:Within the perimetrically intact regions of glaucomatous eyes, the mean VD and RNFL thickness were significantly reduced in inferotemporal, superonasal, and nasal upper peripapillary sectors as compared with healthy eyes (P0.008). The temporal upper sector had reduced mean VD (60.3% vs. 62.9%, P=0.04) despite similar mean RNFL thickness (P=0.18). The superotemporal sector had decreased mean RNFL thickness (121 vs. 138 mu m, P=0.0001) despite similar VD (P=0.06). At the macula, ganglion cell complex thickness was reduced in the superior and inferior hemispheres, but mean VD was reduced in the superior parafoveal region only.Conclusions:Peripapillary and parafoveal vascular changes precede functional decline. The extent of VD reduction and RNFL thinning varies in different peripapillary sectors and longitudinal studies are required to better understand the temporal relationship of vascular and RNFL loss.
机译：目的：研究扇形血管密度（VD）和围属植物和剖腹产血珠的结构改变，对应于半剥离缺陷的肺肺腺眼眼细胞周围完整的区域，并使用光学相干断层扫描将它们与健康的眼睛进行比较。方法：包括这种横断面研究37只眼睛具有视角青光眼，具有视野缺陷，限制为1个半场和45次匹配的对照。在8个扇区中测量百毛细亚植物VD和视网膜神经纤维层（RNFL）厚度。在黄斑的优异和下半球中测量胰膜荚膜vd和神经节细胞复杂厚度。这些参数在青光眼的眼睛的完整血轮腹泻和使用T试验中的相应扇区之间进行比较。结果：在肺螨神经的周末完整区域内，平均VD和RNFL厚度在不等血，超子痫和鼻腔中显着降低与健康的眼睛相比，围网属部门（P <0.008）。尽管平均RNFL厚度相似（p = 0.18），颞上部扇区的平均值降低尽管类似VD（P = 0.06），卓象型扇区的平均rNFL厚度（121与138μm，p = 0.0001）减少（121vs.138μm，p = 0.0001）。在黄斑，在优异的半球中，神经节细胞络合物厚度降低，但仅在高级促剖视图中降低了平均Vd。结论：围毛绒和肺窝血管血管变化在功能下降之前。 VD减少和RNFL稀疏的程度在不同的围栏行业和纵向研究中变化，需要更好地理解血管和RNFL损失的时间关系。

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