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首页> 外文期刊>American journal of Alzheimer's disease and other dementias >Galantamine for the treatment of BPSD in Thai patients with possible Alzheimer's disease with or without cerebrovascular disease.
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Galantamine for the treatment of BPSD in Thai patients with possible Alzheimer's disease with or without cerebrovascular disease.

机译：加兰他敏用于泰国可能伴有或不伴脑血管疾病的阿尔茨海默氏病患者的BPSD治疗。

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OBJECTIVES: This study was to investigate an efficacy of galantamine in treatment of behavioral and psychological symptoms of dementia in Thai elderly who suffered from possible Alzheimer's disease (AD) with or without cerebrovascular disease and vascular dementia. METHODS: A 6-month, multicenter, open-label, uncontrolled trial was undertaken in 75 patients. Eligible patients received an initial galantamine dose of 8 mg/dayand escalated over 5 to 8 weeks to maintenance doses of 16 or 24 mg/day. The behavioral response was assessed as an intention-to-treat analysis using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). RESULTS: Galantamine improved behavioral and psychological symptoms of dementia (P < .05 vs baseline) over the 24 weeks of treatment. BEHAVE-AD score was significantly improved from baseline in paranoid and delusion ideation, diurnal rhythm disturbances, anxieties, and phobias. CONCLUSIONS: Galantamine may be a well-tolerated and effective treatment option for improving psychotic, behavioral, and psychological symptoms in Thai elderly with possible AD with or without cerebrovascular disease and vascular dementia.
机译：目的：本研究旨在探讨加兰他敏对泰国老年人痴呆症的行为和心理症状的治疗效果，该泰国老年人患有可能的阿尔茨海默病（AD），伴或不伴脑血管疾病和血管性痴呆。方法：对75例患者进行了为期6个月的多中心，开放标签，非对照试验。符合条件的患者接受加兰他敏初始剂量为8毫克/天，并在5至8周内逐步提高为维持剂量16或24毫克/天。使用阿尔茨海默氏病病情分级量表（BEHAVE-AD）中的行为病理学，将行为反应评估为意向性治疗分析。结果：加兰他敏在治疗的24周内改善了痴呆的行为和心理症状（与基线相比，P <0.05）。在偏执和妄想，昼夜节律紊乱，焦虑和恐惧症方面，BEHAVE-AD得分较基线明显提高。结论：加兰他敏可能是一种耐受良好的有效治疗选择，可改善泰国老年AD患者伴或不伴脑血管疾病和血管性痴呆的精神病，行为和心理症状。

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