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首页> 外文期刊>Journal of human hypertension >Risk of hypertension among different metabolic phenotypes: a systematic review and meta-analysis of prospective cohort studies
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Risk of hypertension among different metabolic phenotypes: a systematic review and meta-analysis of prospective cohort studies

机译：不同代谢表型的高血压风险：治疗课程研究的系统审查和荟萃分析

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We performed a meta-analysis to assess the association of body mass index (BMI) and metabolic status with the risk of incident hypertension. Relevant studies were identified by searching comprehensive search via PubMed and Scopus search engines up to May 2018 and were analyzed using a random-effects model. Eight prospective studies were included in the analyses with metabolically healthy normal weight (MHNW) as the reference group. Pooled relative risks (RRs) and their 95% confidence intervals (CI) were calculated using random-effects or fixed-effect models when appropriate. Subgroup analysis was applied to define possible sources of heterogeneity. Overall, among 79090 participants, the risk of hypertension in metabolically unhealthy obese (MUHO) and metabolically healthy obese phenotypes (MHO) increased compared with the reference group (pooled effect size = 1.95, 95%CI: 1.87-2.04, P < 0.001 vs pooled effect size: 1.54, 95%CI: 1.48-1.61, P < 0.001, respectively). Also, a significant positive association between metabolically unhealthy normal weight (MUHNW) phenotype and the risk of hypertension was observed (pooled effect size =1.48, 95%CI: 1.41-1.55, P < 0.001). Metabolically unhealthy overweight (MUHOW) and metabolically healthy overweight (MHOW) phenotypes had greater risk of hypertension compared with the MHNW phenotype (pooled effect size = 1.50, 95%CI: 1.13-1.71, P < 0.001 and pooled effect size = 1.18, 95%CI: 1.11-1.27, P < 0.001). This meta-analysis revealed that individuals with metabolic abnormality had a higher risk for hypertension and also suggests that MHOW/ MHO are not a benign condition. We are refuting the notion that overweight and obesity without metabolic abnormalities are benign conditions in all population.
机译：我们进行了荟萃分析，以评估体重指数（BMI）的关联，以及事故高血压风险的代谢地位。通过PubMed和Scopus Search引擎搜索全面搜索到2018年5月，并使用随机效应模型进行分析来确定相关研究。在代谢健康正常重量（MHNW）作为参考组的分析中包含八项前瞻性研究。合并的相对风险（RRS）及其95％置信区间（CI）在适当时使用随机效应或固定效果模型计算。应用亚组分析来定义可能的异质性源。总体而言，在79090名参与者中，与参考组相比，代谢不健康肥胖（MUHO）和代谢健康肥胖表型（MHO）的高血压风险增加（汇总效应= 1.95,95％CI：1.87-2.04，P <0.001 Vs合并效果尺寸：1.54,95％CI：1.48-1.61，分别为P <0.001）。此外，观察到代谢不健康的正常重量（MUHNW）表型和高血压风险之间的显着阳性关系（合并效果= 1.48,95％CI：1.41-1.55，P <0.001）。与MHNW表型相比，代谢不健康的超重（MUHOW）和代谢性健康超重（MHOW）表型具有更大的高血压风险％ci：1.11-1.27，p <0.001）。这种荟萃分析显示，具有代谢异常的个体具有更高的高血压风险，并且还表明MHOW / MHO不是良性状态。我们正在驳斥，没有代谢异常的超重和肥胖是所有人口的良性条件。

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