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首页> 外文期刊>Journal of Infection >Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro
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Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro

机译:肺炎蛋白在体外介导中性粒细胞和血小板的异质型聚集

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摘要

Objectives: Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the pneumococcal toxin, pneumolysin (Ply), activates production of platelet-activating factor (PAF) and thromboxane A(2) (TxA(2)) by neutrophils, these bioactive lipids being potential mediators of neutrophil: platelet (NP) networking.
机译:目的:血小板协调中性粒细胞的炎症活性,可能导致严重的肺炎球菌感染期间的肺和心肌损伤。 该研究测试了肺炎球菌毒素,肺炎蛋白(PLY),激活血小板活化因子(PAF)和血栓素A(2))(TXA(2))的假设,这些生物活性脂质是中性粒细胞的潜在介质:血小板 (NP)网络。

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