A Novel Cytotoxic Prenylated Flavonoid from the Root of Morus alba

Hisayoshi Kofujita; Masashi Yaguchi; Norio Doi; Koichi Suzuki

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A Novel Cytotoxic Prenylated Flavonoid from the Root of Morus alba

机译：来自Morus Alba根的一种新型细胞毒性戊酰化黄酮类化合物

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A novel prenylated flavanone was isolated from ethyl acetate extracts of the hard-wood cutting root of Kinuyutaka, a cultivar of Morus alba. The structure, 7, 2', 4', 6'-tetrahydoroxy-6-geranylflavanone, was revealed by spectral analyses. This prenylated flavanone exhibited cytotoxic activity against rat hepatoma (dRLh84) cells with an IC_(50) of 52.8 μg/ml.

机译：从Kinuyutaka的硬木切割根的乙酸乙酯提取物中分离出一种新的戊酰化黄烷酮，该蛋白质植物的含水蛋白。通过光谱分析揭示了结构，7,2'，4'，6'-四氢罗氧基-6-壬基甲苯酮酮。该戊酰化的黄酮表现出对大鼠肝癌（DRLH84）细胞的细胞毒性活性，其IC_（50）为52.8μg/ mL。

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来源
《Journal of insect biotechnology and sericology》 |2004年第3期|共4页
作者
Hisayoshi Kofujita; Masashi Yaguchi; Norio Doi; Koichi Suzuki;
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作者单位

Faculty of Agriculture Iwate University Ueda 3-18-8 Morioka 020-8550 Japan;

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正文语种 eng
中图分类畜牧、动物医学、狩猎、蚕、蜂;
关键词
Novel prenylated flavanone; Morus alba; root; cytotoxic activity;

机译：新型戊酰胺黄酮;Morus Alba;根;细胞毒性活性;

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专利

1. A Novel Cytotoxic Prenylated Flavonoid from the Root of Morus alba [J] . Hisayoshi Kofujita, Masashi Yaguchi, Norio Doi, Journal of insect biotechnology and sericology . 2004,第3期

机译：来自Morus Alba根的一种新型细胞毒性戊酰化黄酮类化合物
2. Cytotoxic prenylated flavonoids from Morus alba [J] . Nguyen Tien Dat, Phung Thi Xuan Binh, Le Thi Phuong Quynh, Fitoterapia . 2010,第8期

机译：桑白皮的细胞毒性异戊酸类黄酮
3. Prenylated flavonoids as potent phosphodiesterase-4 inhibitors from Morus alba : Isolation, modification, and structure-activity relationship study [J] . Yan-Qiong Guo, Gui-Hua Tang, Lan-Lan Lou, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：戊酰化的黄酮类黄酮，作为来自森属植物的有效磷酸二酯酶-4抑制剂：分离，改性和结构 - 活动关系研究
4. Cytotoxic potential of C-prenylated flavonoids [C] . Karel Smejkal An International Congress on Natural Anticancer Drugs . 2014

机译：C-戊基黄酮类化合物的细胞毒性潜力
5. Genetic and morphological characterization of red mulberry (Morus rubra L.), white mulberry (Morus alba L.) and their hybrids. [D] . Salah, Sally M. 2006

机译：红桑（Morus rubra L.），白桑（Morus alba L.）及其杂种的遗传和形态特征。
6. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response [O] . Peter Kollar, Tomáš Bárta, Jan Hošek, 2013

机译：桑树中的烯丙基黄酮类化合物可抑制THP-1人白血病细胞中G1 / S的转变并阻止脂多糖诱导的炎症反应
7. Three New Isoprenylated Flavonoids from the Root Bark of Morus alba [O] . Jae-Woo Jung, Ji-Hae Park, Yeong-Geun Lee, 2016

机译：白杨根皮中三种新的异戊二烯化黄酮类化合物

A Novel Cytotoxic Prenylated Flavonoid from the Root of Morus alba

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