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首页> 外文期刊>Journal of insect biotechnology and sericology >Accumulation of non-viral 45.5K and 44K polypeptides inversely correlates with that of viral structural polypeptides in the midgut of the silkworm, Bombyx mori, infected with B. mori densovirus type 2.
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Accumulation of non-viral 45.5K and 44K polypeptides inversely correlates with that of viral structural polypeptides in the midgut of the silkworm, Bombyx mori, infected with B. mori densovirus type 2.

机译：非病毒45.5k和44k多肽的积累与蚕子虫，Bombyx Mori的中肠中的病毒结构多肽的累积与B. Mori Densovirus型2型感染。

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摘要

Non-viral 45.5K and 44K polypeptides have been shown to accumulate in virus-infected degenerate cells in the midgut epithelium of the silkworm, Bombyx mori. These polypeptides are detectable first temporally at around 3 days postinfection (pi) and then persistently at around 8 days pi onwards, when day 1 fifth-instar larvae of the silkworm are infected with B. mori densovirus type 2 (BmDNV-2). In this study, we found that the amount of 45.5K and 44K polypeptides accumulated in BmDNV-2-infected midgut epithelium was inversely correlated with that of BmDNV-2 structural polypeptides. TUNEL staining showed that the degeneration of BmDNV-2-infected cells enriched in 45.5K and 44K polypeptides was not due to apoptosis. These results suggest that 45.5K and 44K polypeptides are involved in the clearance of the cells damaged by virus multiplication from BmDNV-2-infected midgut epithelium by a mechanism different from apoptosis induction, resulting in a restricted accumulation of viruses in BmDNV-2-infected midgut epithelium..
机译：已经证明了非病毒45.5k和44k多肽在家蚕的中间肠道上皮中的病毒感染的简并细胞中积累。这些多肽首先在禁食（PI）左右3天后首先检测到，然后在8天左右的PI持续存在，当蚕的第5天龄幼虫感染B. Mori Densovirus 2（BMDNV-2）时。在这项研究中，我们发现，在BMDNV-2感染的中间体上皮中积累的45.5k和44k多肽的量与BMDNV-2结构多肽的累积呈逆。 TUNEL染色表明，富含45.5K和44K多肽的BMDNV-2感染细胞的退化不是由于细胞凋亡。这些结果表明，45.5K和44K多肽参与通过与凋亡诱导不同的机制来自BMDNV-2感染的中间菌上皮的病毒倍增的细胞的间隙。在BMDNV-2感染中受到限制病毒的累积中肠上皮..

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