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首页> 外文期刊>Journal of industrial and engineering chemistry >Engineered horseradish peroxidase-catalyzed hydrogels with high tissue adhesiveness for biomedical applications
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Engineered horseradish peroxidase-catalyzed hydrogels with high tissue adhesiveness for biomedical applications

机译：具有高组织粘合性的生物医学应用的工程化辣根过氧化物酶催化水凝胶

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摘要

Adhesive hydrogels offer considerable potential in biomedical applications because of the excellent integration between materials and tissues. Horseradish peroxidase (HRP)-catalyzed hydrogelation, with advantages that include ease of handling, simplicity in material design, high biocompatibility, and processability, is becoming a promising candidate to be engineered as an adhesive hydrogel. This review summarizes recent development of HRP-mediated hydrogelation towards the bioadhesive field, and other applications requiring the tissue adhesion of hydrogels. From the viewpoint of adhesive hydrogel designation, the basic chemistry of the adhesive mechanism, combinations of interactions, and currently commercial bioglues are summarized. The review recapitulated the adhesive hydrogel applications, the clinical translation ability, the controlling hydrogelation kinetics, the related physicochemical characteristics, cytotoxicity, and animal studies. Looking to the future, to make more substantial contributions to the bioadhesive field, or to various biomedical applications, higher adhesion should be continuously improved, and greater emphasis should be placed on clinical trials. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
机译：由于材料和组织之间的优异集成，粘合水凝胶在生物医学应用中提供了相当大的潜力。辣根过氧化物酶（HRP） - 催化水胶质，具有优点，包括易于处理，材料设计的简单性，高生物相容性和加工性，正在成为被设计为粘合水凝胶的有希望的候选者。本综述总结了HRP介导的HRP介导的水凝矿朝向生物粘附田的开发，以及需要组织粘附水凝胶的其他应用。从粘合水凝胶名称的观点来看，总结了粘合机构的基本化学，相互作用的组合，以及目前的商业生物帘线。审查综合综合粘合水凝胶应用，临床翻译能力，控制水胶质动力学，相关的物理化学特征，细胞毒性和动物研究。展望未来，为生物粘性领域做出更大的贡献，或者对各种生物医学应用，应持续改善更高的粘合性，并且应更加强调临床试验。 （c）2019年韩国工程化学学会。 elsevier b.v出版。保留所有权利。

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