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首页> 外文期刊>Journal of industrial and engineering chemistry >High-performance hepatobiliary dysprosium contrast agent for ultra-high-field magnetic resonance imaging
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High-performance hepatobiliary dysprosium contrast agent for ultra-high-field magnetic resonance imaging

机译：用于超高场磁共振成像的高性能肝胆镝对比剂

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Ultra-high-field (UHF) magnetic resonance imaging (MRI) can open up new avenues in clinical diagnostic imaging. Its sensitivity can be further improved using contrast agents (CAs). Therefore, developing lowmolecular-weight MR CAs that are efficient under UHF is crucial to ensure taking full advantage of MR imaging at UHF. Moreover, designing highly stable UHF liver-specific CA has been challenging. Here, using dysprosium (Dy3+), which relaxes water protons via a Curie relaxation that increases T-2 relaxation substantially with the magnetic field strength, we report a new macrocyclic liver specific Dy3+ complex (Dy[DO3A-EOB]). We observed a 7.06 times higher r(2)/r(1) ratio of Dy[DO3A-EOB] at 9.4 T than that of 1.5 T, which suggests a superior negative-enhancing MR CA at UHF. In vivo MR imaging results further demonstrated that Dy[DO3A-EOB] showed a much strong negative enhancement at UHF (9.4T) than under a low field (1.5 T). It was also found that, in addition to the ligand structure, the metal itself plays an important role in determining the liver uptake pattern of the CA. Therefore, we successfully demonstrated the first example of a small-molecular-weight liver-specific Dy3+ complex acting as a T-2 CA with high sensitivity at UHF for diagnosis of liver diseases. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
机译：超高场（UHF）磁共振成像（MRI）可以在临床诊断成像中开辟新的途径。使用造影剂（CAS）可以进一步改善其敏感性。因此，显影在UHF下有效的低分子重量MR CAS至关重要，以确保在UHF中充分利用成像先生。此外，设计高度稳定的UHF肝脏特异性CA一直在具有挑战性。这里，使用镝（DY3 +），通过居里弛豫释放水质子，其基本上随着磁场强度提高T-2弛豫，我们报告了一种新的宏环肝脏特异性DY3 +复合物（DYγ-eob]）。我们观察到Dy [Do3a-eob]的7.06倍较高的R（2）/ R（1）比，而不是1.5吨，这表明在UHF的优越性负增强Ca。在体内MR成像结果进一步证明DY [DO3A-EOB]在UHF（9.4T）下表现出比低场（1.5吨）的强度强度增强。还发现，除了配体结构之外，金属本身在确定CA的肝脏吸收模式方面发挥着重要作用。因此，我们成功地证明了小分子量肝脏特异性DY3 +复合物的第一实例，其作为T-2 Ca具有高灵敏度，用于诊断肝脏疾病。 （c）2020朝鲜工业与工程化学学会。 elsevier b.v出版。保留所有权利。

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