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Soyprotein Fibers with High Strength and Water Stability for Potential Medical Applications

机译：潜在医学应用中具有高强度和水稳定性的大豆蛋白纤维

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摘要

Fibers with mechanical properties and water stability suitable for tissue engineering have been developed from soyproteins. Proteins are biocompatible and biodegradable and are preferred over synthetic polymers for medical applications. Although plant proteins are abundant and inexpensive and can be made into various types of scaffolds, very few attempts have been made to understand the suitability of using plant proteins for medical applications, especially as fibrous substrates for tissue engineering. So far, it has not been able to obtain good quality soyprotein fibers without using toxic crosslinking agents or blending soyprotein with synthetic polymers. In this research, we have developed 100% soyprotein fibers with good strength and water stability without using any external crosslinking agents. The soyprotein fibers have better wet strength than collagen fibers and are conducive to the attachment, growth, and proliferation of mouse fibroblasts. Fibers are better substrates than films for growth and orientation of cells and are therefore preferable for tissue engineering applications. Soyprotein fibers show good potential to be novel biomaterials with properties suitable for tissue engineering and other medical applications.
机译：已经从大豆蛋白中开发出了适合组织工程的具有机械性能和水稳定性的纤维。蛋白质具有生物相容性和生物可降解性，在医学上优于合成聚合物。尽管植物蛋白既丰富又便宜，并且可以制成各种类型的支架，但很少有人尝试了解将植物蛋白用于医学应用的适用性，特别是作为组织工程的纤维基质。迄今为止，如果不使用有毒的交联剂或将大豆蛋白与合成聚合物混合，就无法获得高质量的大豆蛋白纤维。在这项研究中，我们开发了100％的大豆蛋白纤维，具有良好的强度和水稳定性，而无需使用任何外部交联剂。大豆蛋白纤维比胶原蛋白纤维具有更好的湿强度，并且有利于小鼠成纤维细胞的附着，生长和增殖。对于细胞的生长和定向，纤维是比薄膜更好的基材，因此对于组织工程应用是优选的。大豆蛋白纤维具有成为具有适合组织工程和其他医学应用性能的新型生物材料的潜力。

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