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首页> 外文期刊>Journal of Lipid Research >Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients
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Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients

机译：在2型糖尿病患者的间质液中出乎意料地降低了致动脉膜的水平

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At a given level of serum cholesterol, patients with T2D have an increased risk of developing atherosclerosis compared with nondiabetic subjects. We hypothesized that T2D patients have an increased interstitial fluid (IF)-to-serum gradient ratio for LDL, due to leakage over the vascular wall. Therefore, lipoprotein profiles in serum and IF from 35 T2D patients and 35 healthy controls were assayed using fast performance liquid chromatography. The IF-to-serum gradients for VLDL and LDL cholesterol, as well as for apoB, were clearly reduced in T2D patients compared with healthy controls. No such differences were observed for HDL cholesterol. Contrary to our hypothesis, the atherogenic VLDL and LDL particles were not increased in IF from diabetic patients. Instead, they were relatively sparser than in healthy controls. The most probable explanation to our unexpected finding is that these lipoproteins are more susceptible to retainment in the extravascular space of these patients, reflecting a more active uptake by, or adhesion to, tissue cells, including macro-phages in the vascular wall.fiS Further studies are warranted to further characterize the mechanisms underlying these observations, which may be highly relevant for the understanding of why the propensity to develop atherosclerosis is increased in T2D.Apro, J., P. Parini, A. Broijersen, B. Angelin, and M. Rudling. Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients. J. Lipid Res. 2015. 56: 1633-1639.
机译：在给定水平的血清胆固醇水平，与非糖尿病受试者相比，T2D患者的风险增加了发展动脉粥样硬化。我们假设T2D患者由于血管壁泄漏而导致LDL的间质液（IF）-TO-血清梯度率增加。因此，使用快速性能液相色谱法测定血清中的脂蛋白谱和35个T2D患者和35例健康对照。与健康对照相比，T2D患者的VLDL和LDL胆固醇以及APOB的IF-to-in-血清梯度明显降低。对于HDL胆固醇没有观察到这种差异。与我们的假设相反，如果来自糖尿病患者，致动脉发生VLDL和LDL颗粒不会增加。相反，它们比健康的控制相对稀疏。对我们意外发现的最可能的解释是，这些脂蛋白在这些患者的血管外空间中更容易保留，反映出更积极的吸收或粘附的组织细胞，包括血管壁中的宏观噬菌体.FIS进一步有必要研究进一步表征了这些观察结果的机制，这对理解为什么在T2D.Apro，J.Apro，A.Broijersen，B. Angelin和B. Angelin和B. Angelin和M.磨损。在2型糖尿病患者的间质液中出乎意外地减少了致动脉膜的水平。 J. Lipid Res。 2015. 56：1633-1639。

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