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首页> 外文期刊>Journal of mass spectrometry: JMS >The transformation from 2°‐amine to 3°‐amine of cyclam ring alters the fragmentation patterns of 1‐tosylcytosine‐cyclam conjugates
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The transformation from 2°‐amine to 3°‐amine of cyclam ring alters the fragmentation patterns of 1‐tosylcytosine‐cyclam conjugates

机译：从2° - 胺至3° - 氨锡环的转化改变了1-甲蛋白胞嘧啶-cycnam缀合物的碎片模式

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Abstract > The novel N ‐1‐sulfonylcytosine‐cyclam conjugates 1 and 2 conjugates are ionized by electrospray ionization mass spectrometry (ESI MS) in positive and negative modes (ES + and ES ? ) as singly protonated/deprotonated species or as singly or doubly charged metal complexes. Their structure and fragmentation behavior is examined by collision induced experiments. It was observed that the structure of the conjugate dictated the mode of the ionization: 1 was analyzed in ES ? mode while 2 in positive mode. Complexation with metal ions did not have the influence on the ionization mode. Zn 2+ and Cu 2+ complexes with ligand 1 followed the similar fragmentation pattern in negative ionization mode. > The transformation from 2°‐amine in 1 to 3°‐amine of cyclam ring in 2 leads to the different fragmentation patterns due to the modification of the protonation priority which changed the fragmentation channels within the conjugate itself. Cu 2+ ions formed complexes practically immediately, and the priority had the cyclam portion of the ligand 2 . The structure of the formed Zn 2+ complexes with ligand 2 depended on the number of 3° amines within the cyclam portion of the conjugate and the ratio of the metal:ligand used. The cleavage of the cyclam ring of metal complexes is driven by the formation of the fragment that suited the coordinating demand of the m </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >小说 n - 磺酰胞氨酰胞嘧啶-capaM缀合物 1 / b>和缀合物通过电喷雾电离质谱（ESI MS）在正极和阴性模式下电离（ ES + </ sup>和ES </ sup>）作为单独质子/质子化物种或单独或双电荷金属配合物。通过碰撞诱导的实验检查它们的结构和碎片行为。观察到，缀合物的结构决定了在阳性模式下在ES β-η中进行的电离模式： 1 / b>。与金属离子的络合没有对电离模式的影响。 Zn 2 + </ sup>和Cu 2 + </ sup>配合物用配体 1 </ b>在负电离模式下进行类似的碎片模式。 </ p> >在 1 / b>中的2°-amine在 2/b>中为3° - 胺导致不同的碎片模式，由于修改质子化优先级改变了共轭本身内的碎片通道。 Cu 2 + </ sup>离子实际地立即形成络合物，优先级具有配体 2的循环部分。用配体β3/ b>的形成的Zn 2 + / sup>配合物的结构依赖于缀合物的循环物中的循环系中的3°胺的数量和金属：配体使用的比例。金属配合物的循环环的裂解是由适用于M的配位需求的片段的形成驱动 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kobeti? Renata&option=202" target="_blank" rel="nofollow">Kobeti? Renata;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klju?ari? Valentina&option=202" target="_blank" rel="nofollow">Klju?ari? Valentina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Safti? Dijana&option=202" target="_blank" rel="nofollow">Safti? Dijana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mati? Josipa&option=202" target="_blank" rel="nofollow">Mati? Josipa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ban ?eljka&option=202" target="_blank" rel="nofollow">Ban ?eljka;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kazazi? Snje?ana&option=202" target="_blank" rel="nofollow">Kazazi? Snje?ana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=?ini? Biserka&option=202" target="_blank" rel="nofollow">?ini? Biserka;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Laboratory for Biomolecular Interactions and Spectroscopy Division of Organic Chemistry and BiochemistryRu?er Bo?kovi? InstituteBijeni?ka cesta 54 10 000 Zagreb Croatia;</p> <p>Ministry of Defense of the Republic of CroatiaDr. Franjo Tu?man Croatian Defense AcademyIlica 256 b Zagreb Croatia;</p> <p>Laboratory for Biomolecular Interactions and Spectroscopy Division of Organic Chemistry and BiochemistryRu?er Bo?kovi? InstituteBijeni?ka cesta 54 10 000 Zagreb Croatia;</p> <p>Laboratory for Biomolecular Interactions and Spectroscopy Division of Organic Chemistry and BiochemistryRu?er Bo?kovi? InstituteBijeni?ka cesta 54 10 000 Zagreb Croatia;</p> <p>Laboratory for Biomolecular Interactions and Spectroscopy Division of Organic Chemistry and BiochemistryRu?er Bo?kovi? InstituteBijeni?ka cesta 54 10 000 Zagreb Croatia;</p> <p>Laboratory for Mass Spectrometry Division of Physical ChemistryRu?er Bo?kovi? InstituteBijeni?ka cesta 54 10 000 Zagreb Croatia;</p> <p>Laboratory for Biomolecular Interactions and Spectroscopy Division of Organic Chemistry and BiochemistryRu?er Bo?kovi? InstituteBijeni?ka cesta 54 10 000 Zagreb Croatia;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cu 2+ and Zn 2+ complexes&option=203" rel="nofollow">Cu 2+ and Zn 2+ complexes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cyclam conjugate&option=203" rel="nofollow">cyclam conjugate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ESI‐MS&option=203" rel="nofollow">ESI‐MS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fragmentation reactions N ‐ 1‐tosylcytosine ring stability&option=203" rel="nofollow">fragmentation reactions N ‐ 1‐tosylcytosine ring stability;</a> </p> <div class="translation"> 机译：Cu 2+和Zn 2+复合物;锡克缀合物;ESI-MS;碎片反应N - 1-甲苯胞菌环稳定性; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025633051.html">The transformation from 2°‐amine to 3°‐amine of cyclam ring alters the fragmentation patterns of 1‐tosylcytosine‐cyclam conjugates</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kobeti? 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<span> <a href="/journal-cn-4634/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 湖南大学学报（自然科学版） </a> </span> <span> . 2002</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-31983_thesis/02022483425.html">通过改变给体(donor)侧臂调控二氮环系的Cu(Ⅱ)配合物的配位模式和性质</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杜淼&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杜淼</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=商志良&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,商志良</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张若桦&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张若桦</a> <span> <a href="/conference-cn-31983/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国化学会全国第五届无机化学学术会议 </a> <span> <span> . 2000</span> </span> </div> 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