Myofiber metabolic type determination by mass spectrometry imaging

Centeno Delphine; Venien Annie; Pujos-Guillot Estelle; Astruc Thierry; Chambon Christophe; Theron Laetitia

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Myofiber metabolic type determination by mass spectrometry imaging

机译：MyoFiber代谢类型通过质谱法测定

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Matrix assisted laser desorption/ ionization (MALDI) mass spectrometry imaging is a powerful tool that opens new research opportunities in the field of biology. In thiswork, predictive modelwas developed to discriminatemetabolic myofiber types using the MALDI spectral data. Rat skeletal muscles are constituted of type I and type IIA fiber, which have an oxidative metabolism for glycogen degradation, and type IIX and type IIB fiber which have a glycolytic metabolism, present in different proportions according to the muscle function and physiological state. So far, myofiber type is determined by histological methods that are time consuming.

机译：矩阵辅助激光解吸/电离（MALDI）质谱成像是一种强大的工具，在生物学领域开启新的研究机会。在本文中，使用MALDI光谱数据开发出用于鉴别致密地相同的MyoFiber类型的预测模型。大鼠骨骼肌由I型和IIA型纤维构成，其对糖原降解具有氧化代谢，并且型IIX和型IIB纤维具有根据肌肉功能和生理状态的不同比例存在于不同比例中。到目前为止，MyoFiber型由组织学方法确定，这些方法是耗时的。

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来源
《Journal of mass spectrometry: JMS》 |2017年第8期|共4页
作者
Centeno Delphine; Venien Annie; Pujos-Guillot Estelle; Astruc Thierry; Chambon Christophe; Theron Laetitia;
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作者单位

Univ Clermont Auvergne UNH INRA Plateforme Explorat Metab PFEM F-63000 Clermont Ferrand France;

Univ Clermont Auvergne INRA Auvergne Rhone Alpes Qual Prod Anim UR370 F-63122 St Genes Champanelle France;

Univ Clermont Auvergne UNH INRA Plateforme Explorat Metab PFEM F-63000 Clermont Ferrand France;

Univ Clermont Auvergne INRA Auvergne Rhone Alpes Qual Prod Anim UR370 F-63122 St Genes Champanelle France;

Univ Clermont Auvergne UNH INRA Plateforme Explorat Metab PFEM F-63000 Clermont Ferrand France;

Univ Clermont Auvergne UNH INRA Plateforme Explorat Metab PFEM F-63000 Clermont Ferrand France;

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原文格式 PDF
正文语种 eng
中图分类分析化学;
关键词
MALDI imaging; mass spectrometry; muscle; myofiber metabolic type;

机译：MALDI成像;质谱;肌肉;MyoFiber代谢类型;

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专利

1. Myofiber metabolic type determination by mass spectrometry imaging [J] . Centeno Delphine, Venien Annie, Pujos-Guillot Estelle, Journal of mass spectrometry: JMS . 2017,第8期

机译：MyoFiber代谢类型通过质谱法测定
2. Characterization of myofiber-type-specific molecules using mass spectrometry imaging [J] . Goto-Inoue Naoko, Morisasa Mizuki, Machida Kazumasa, Rapid Communications in Mass Spectrometry: RCM . 2019,第Suppla2期

机译：使用质谱法成像表征肌纤维型特异性分子
3. Determination of Synthetic Impurities and Metabolic Products of F-ADAM, a Positron Emission Tomography Imaging Agent for Serotonin Transporter (SERT) Using HPLC-Tandem Mass Spectrometry [J] . Wei-Hsi Chen, Chyng-Yann Shiue Advances in Biological Chemistry . 2020,第10期

机译：使用HPLC - 串联质谱法测定F-ADAM的合成杂质和F-ADAM的代谢产物，用于血清素转移仪（SERT）的正电子发射体显影剂
4. A Novel Method for the Determination of the Site of Metabolic Substitution by Ion Mobility Spectrometry-Mass Spectrometry [C] . Atsushi Shimizu, Tomoyuki Ohe, Masato Chiba American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：一种新的离子迁移光谱分质谱法测定代谢替代位点的方法
5. Determination of fifty-six elements in three distinct types of geological materials by inductively coupled plasma-mass spectrometry. [D] . Guo, Caixia. 1996

机译：电感耦合等离子体质谱法测定三种不同类型地质材料中的五十六种元素
6. METB-10. EVALUATION OF NON-SUPERVISED MATRIX-ASSISTED LASER DESORPTION / IONIZATION MASS SPECTROMETRY IMAGING (MALDI) MASS SPECTROMETRY IMAGING (MSI) COMBINED WITH MICROPROTEOMICS FOR DETERMINATION OF GLIOBLASTOMA HETEROGENEITY [O] . Emilie Le Rhun, Marie Duhamel, Lauranne Drelich, 2017

机译：METB-10。非监督矩阵辅助激光解吸/电离质谱成像（MALDI）质谱结合微蛋白质组学评估胶质母细胞异质性的评估
7. Myofiber metabolic type determination by mass spectrometry imaging [O] . Delphine Centeno, Annie Vénien, Estelle Pujos-Guillot, 2017

机译：MyoFiber代谢型通过质谱法测定

Myofiber metabolic type determination by mass spectrometry imaging

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