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首页> 外文期刊>Journal of mass spectrometry: JMS >Charge transfer dissociation of phosphocholines: gas-phase ion/ion reactions between helium cations and phospholipid cations
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Charge transfer dissociation of phosphocholines: gas-phase ion/ion reactions between helium cations and phospholipid cations

机译：磷光籽的电荷转移解离：氦阳离子和磷脂阳离子之间的气相离子/离子反应

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Phospholipid cations formed by electrospray ionization were subjected to excitation and fragmentation by a beam of 6 keV helium cations in a process termed charge transfer dissociation (CTD). The resulting fragmentation pattern in CTD is different from that of conventional collision-induced dissociation, but analogous to that of metastable atom-activated dissociation and electron-induced dissociation. Like collision-induced dissociation, CTD yields product ions indicative of acyl chain lengths and degrees of unsaturation in the fatty acyl moieties but also provides additional structural diagnostic information, such as double bond position. Although CTD has not been tested on a larger lipid sample pool, the extent of structural information obtained demonstrates that CTD is a useful tool for lipid structure characterization, and a potentially useful tool in future lipidomics workflows. CTD is relatively unique in that it can produce a relatively strong series of 2+ product ions with enhanced abundance at the double bond position. The generally low signal-to-noise ratios and spectral complexity of CTD make it less appealing than OzID or other radical-induced methods for the lipids studies here, but improvements in CTD efficiency could make CTD more appealing in the future. Copyright (C) 2017 John Wiley & Sons, Ltd.
机译：通过电喷雾电离形成的磷脂阳离子在称为电荷转移解离（CTD）的过程中，通过6keV氦阳离子的梁进行激发和破碎。 CTD中所得的碎片模式与常规碰撞诱导的解离的不同之处不同，而是与亚稳原子激活的解离和电子诱导的解离的不同之处不同。与碰撞诱导的解离一样，CTD产生指示酰基链长度的产物离子和脂肪酰基部分中的不饱和度，但也提供额外的结构诊断信息，例如双键位置。虽然CTD尚未在较大的脂质样品池上进行测试，但所获得的结构信息的程度表明CTD是脂质结构表征的有用工具，以及未来的脂质谱系工作流程中的潜在有用的工具。 CTD相对独特，因为它可以在双键位置处产生相对强大的2+产品离子系列，在双键位置处具有增强的丰度。 CTD的一般低信噪比和光谱复杂度使其比臭氧或其他自由基诱导的脂质研究方法在此处的吸引力不那么吸引，但CTD效率的改善可以使CTD在未来更具吸引力。版权所有（c）2017 John Wiley＆Sons，Ltd。

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