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首页> 外文期刊>Journal of mass spectrometry: JMS >A comprehensive in vitroin vitro and in vivoin vivo metabolism study of hydroxysafflor yellow AA
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A comprehensive in vitroin vitro and in vivoin vivo metabolism study of hydroxysafflor yellow AA

机译：一个全面的体外和在vivo 的vivo新陈代谢研究黄色 a a

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Abstract > As the most important marker component in <fc> <fi>Carthamus tinctorius</fi> </fc> L., hydroxysafflor yellow A (HSYA) was widely used in the prevention and treatment of cardiovascular diseases, due to its effect of improving blood supply, suppressing oxidative stress, and protecting against ischemia/reperfusion. In this paper, both an in vitro microsomal incubation and an in vivo animal experiment were conducted, along with an LC‐Q‐TOF/MS instrument and a 3‐step protocol, to further explore the metabolism of HSYA. As a result, a total of 10 metabolites were searched and tentatively identified in plasma, urine, and feces after intravenous administration of HSYA to male rats, although no obvious biotransformation was found in the simulated rat liver microsomal system. The metabolites detected involving both phase I and phase II metabolism including dehydration, deglycosylation, methylation, and glucuronic acid conjugation. A few of the metabolites underwent more than one‐step metabolic reactions, and some have not been reported before. The study would contribute to a further understanding of the metabolism of HSYA and provide scientific evidence for its pharmacodynamic mechanism research and clinical use. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >作为<FC> <FI> Carthamus TINTICORIUS </ FI> </ FI> L.，羟基烷烃黄色A（HSYA）的最重要标记组件被广泛用于预防和治疗心血管疾病，由于其改善血液供应，抑制氧化应激，保护缺血/再灌注。本文进行了体外微粒体培养和体内动物实验，以及LC-Q-TOF / MS仪器和3步方案，以进一步探索HSSEA的代谢。结果，总共10种代谢物在血浆，尿液和粪便中被搜查和暂时鉴定到血管对雄性大鼠的静脉内，尿液和粪便中，尽管在模拟大鼠肝微粒体系统中没有发现明显的生物转化。检测到代谢物，涉及相I和II期代谢包括脱水，脱糖基化，甲基化和葡糖醛酸缀合。几种代谢物接受了不止一步的代谢反应，并尚未以前报道。该研究将有助于进一步了解HSYA的新陈代谢，为其药效学机制研究和临床使用提供科学证据。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第2期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Liang&option=202" target="_blank" rel="nofollow">Wu Liang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tang Yuping&option=202" target="_blank" rel="nofollow">Tang Yuping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shan Chenxiao&option=202" target="_blank" rel="nofollow">Shan Chenxiao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chai Chuan&option=202" target="_blank" rel="nofollow">Chai Chuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhou Zhu&option=202" target="_blank" rel="nofollow">Zhou Zhu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shi Xuqin&option=202" target="_blank" rel="nofollow">Shi Xuqin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ding Ning&option=202" target="_blank" rel="nofollow">Ding Ning;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jiaying&option=202" target="_blank" rel="nofollow">Wang Jiaying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lin Liping&option=202" target="_blank" rel="nofollow">Lin Liping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tan Renxiang&option=202" target="_blank" rel="nofollow">Tan Renxiang;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>State Key Laboratory Cultivation Base for TCM Quality and EfficacyNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>State Key Laboratory Cultivation Base for TCM Quality and EfficacyNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>Analytical Instrumentation Center School of PharmacyNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>Analytical Instrumentation Center School of PharmacyNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>Thomas J. Long School of Pharmacy and Health SciencesUniversity of the PacificStockton CA 95211 USA;</p> <p>State Key Laboratory Cultivation Base for TCM Quality and EfficacyNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>Center for Drug Safety Evaluation and Research School of Medicine and Life SciencesNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>Center for Drug Safety Evaluation and Research School of Medicine and Life SciencesNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>State Key Laboratory Cultivation Base for TCM Quality and EfficacyNanjing University of Chinese MedicineNanjing 210023 China;</p> <p>State Key Laboratory Cultivation Base for TCM Quality and EfficacyNanjing University of Chinese MedicineNanjing 210023 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydroxysafflor yellow A (HSYA)&option=203" rel="nofollow">hydroxysafflor yellow A (HSYA);</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LC‐Q‐TOF/MS&option=203" rel="nofollow">LC‐Q‐TOF/MS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=metabolic profile&option=203" rel="nofollow">metabolic profile;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=structural elucidation&option=203" rel="nofollow">structural elucidation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=traditional herbal medicine&option=203" rel="nofollow">traditional herbal medicine;</a> </p> <div class="translation"> 机译：Hydroxafflor黄色A（HSYA）;LC-Q-TOF / MS;代谢型材;结构阐明;传统草药; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025633304.html">A comprehensive <i xmlns="http://www.wiley.com/namespaces/wiley">in vitroin vitro and <i xmlns="http://www.wiley.com/namespaces/wiley">in vivoin vivo metabolism study of hydroxysafflor yellow <fc xmlns="http://www.wiley.com/namespaces/wiley">A</fc>A</a> <b>[J]</b> . <span> <a 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