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首页> 外文期刊>Journal of mass spectrometry: JMS >Metabolomics in the clinic: A review of the shared and unique features of untargeted metabolomics for clinical research and clinical testing
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Metabolomics in the clinic: A review of the shared and unique features of untargeted metabolomics for clinical research and clinical testing

机译：诊所的代谢组学：对临床研究和临床检测的未标准性代谢学的共同和独特特征述评

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摘要

For over a decade, metabolomics has been promising to transform the practice of medicine by delivering powerful diagnostic tests. The reality, however, is that the march towards precision medicine has been slower than first anticipated because of the substantial challenges associated with the development, validation and adoption of complex multivariate testing strategies within a highly regulated environment. In this issue, Kennedy and colleagues present their vision for the future of untargeted metabolomics in clinical testing. They highlight the complexities of test design, accurate and precise data acquisition, quality control, data processing and biochemical pathway analysis when hundreds to thousands of unique metabolites are measured in a single clinical sample. The authors outline the current state of (mass spectrometry-based) metabolomics and illustrate the both the potential, and the challenges, of this rapidly evolving landscape.
机译：多年来，代谢组学一直在有希望通过提供强大的诊断测试来改变医学的做法。 然而，现实是，由于与高度监管环境中复杂多变量测试策略相关的大量挑战，朝着精密药的3月迈向精密药的速度慢。 在这个问题中，肯尼迪和同事们在临床试验中展示了未来未明确的代谢组学的愿景。 它们突出了测试设计，准确和精确的数据采集，质量控制，数据处理和生化途径分析的复杂性，当时在单一临床样本中测量数百至数千个独特的代谢物。 作者概述了当前状态（基于质谱）的代谢组科，并说明了这种快速发展的景观的潜在和挑战。

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