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首页> 外文期刊>Journal of Mathematical Biology >Getting in shape and swimming: the role of cortical forces and membrane heterogeneity in eukaryotic cells
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Getting in shape and swimming: the role of cortical forces and membrane heterogeneity in eukaryotic cells

机译：塑造和游泳：皮质力和膜异质性在真核细胞中的作用

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Recent research has shown that motile cells can adapt their mode of propulsion to the mechanical properties of the environment in which they find themselvescrawling in some environments while swimming in others. The latter can involve movement by blebbing or other cyclic shape changes, and both highly-simplified and more realistic models of these modes have been studied previously. Herein we study swimming that is driven by membrane tension gradients that arise from flows in the actin cortex underlying the membrane, and does not involve imposed cyclic shape changes. Such gradients can lead to a number of different characteristic cell shapes, and our first objective is to understand how different distributions of membrane tension influence the shape of cells in an inviscid quiescent fluid. We then analyze the effects of spatial variation in other membrane properties, and how they interact with tension gradients to determine the shape. We also study the effect of fluid-cell interactions and show how tension leads to cell movement, how the balance between tension gradients and a variable bending modulus determine the shape and direction of movement, and how the efficiency of movement depends on the properties of the fluid and the distribution of tension and bending modulus in the membrane.
机译：最近的研究表明，动机细胞可以使其推进模式适应环境的机械性质，在其中在其他环境中在某些环境中发现自己在其他环境中。后者可以通过BLEBBIBT或其他循环形状变化涉及运动，并且先前已经研究了这些模式的高度简化和更现实的模型。在此，我们研究由膜张力梯度驱动的游泳，该膜张力梯度从膜下面的肌动蛋白皮质中的流动产生，并且不涉及施加的循环形状变化。这种梯度可以导致许多不同的特征细胞形状，并且我们的第一个目的是了解膜张力的不同分布如何影响抗体静态流体中细胞的形状。然后，我们分析了其他膜特性的空间变化的影响，以及它们如何与张力梯度相互作用以确定形状。我们还研究了流体 - 细胞相互作用的影响，并展示了张力如何导致细胞运动，张紧梯度和可变弯曲模量之间的平衡如何确定运动的形状和方向，以及运动效率如何取决于所在的性质膜中的流体和张力的分布和弯曲模量。

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