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首页> 外文期刊>Biotechnology Progress >Minimal reaction sets for Escherichia coli metabolism under differentgrowth requirements and uptake environments
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Minimal reaction sets for Escherichia coli metabolism under differentgrowth requirements and uptake environments

机译：不同生长要求和吸收环境下大肠杆菌代谢的最小反应集

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摘要

A computational procedure for identifying the minimal set of metabolic reactions capable of supporting various growth rates on different substrates is introduced and applied to a flux balance model of the Escherichia coli metabolic network. This task is posed mathematically as a generalized network optimization problem. The minimal reaction sets capable of supporting specified growth rates are determined for two different uptake conditions: (i) limiting the uptake of organic material to a single organic component (e.g., glucose or acetate) and (ii) allowing the importation of any metabolite with available cellular transport reactions. We find that minimal reaction network sets are highly dependent on the uptake environment and the growth requirements imposed on the network. Specifically, we predict that the E. coli network, as described by the flux balance model, requires 224 metabolic reactions to support growth on a glucose-only medium and 229 for an acetate-only medium, while only 122 reactions enable growth on a specially engineered growth medium.
机译：介绍了一种用于识别能够支持不同底物上不同生长速率的最小代谢反应集的计算程序，并将其应用于大肠杆菌代谢网络的流量平衡模型。在数学上将此任务视为广义的网络优化问题。对于两种不同的摄取条件，确定了能够支持特定生长速率的最小反应组：（i）将有机物质的摄取限制为单一有机成分（例如葡萄糖或乙酸盐）;（ii）允许任何代谢物与可用的细胞转运反应。我们发现最小的反应网络集高度依赖于摄取环境和对网络施加的增长要求。具体而言，我们预测，如通量平衡模型所描述的那样，大肠杆菌网络需要224个代谢反应来支持仅葡萄糖培养基上的生长，而229仅需要乙酸盐培养基上的生长，而只有122个反应才能在特殊的培养基上生长。工程生长培养基。

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