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首页> 外文期刊>Journal of Mechanical Science and Technology >Analysis of nonlinear bioheat transfer equation in magnetic fluid hyperthermia
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Analysis of nonlinear bioheat transfer equation in magnetic fluid hyperthermia

机译：磁流体热疗中非线性生物发热方程分析

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The objective of this study is to examine the role of blood perfusion in magnetic fluid hyperthermia by drug delivery. Although increasing blood perfusion due to high local temperature difference refers to the intelligent response of the human body, some researchers are accustomed to employing a constant rate of blood perfusion in the bioheat transfer equation. In this study, we considered a variable volumetric rate for blood perfusion in tissue, experimentally and numerically by Galerkin method. To validate the results obtained from numerical methods, an experimental procedure proposed. Furthermore, in order to transfer magnetic fluid by drug delivery, infusion pomp by which the saline serum with nanoparticles through the vein and artery was employed to make a spherical distribution in tissue. This circulation made it possible to transfer nanoparticles to tissue without any injection. After 60 minutes and changing the dark color of the saline serum to light clear, high amount of nanoparticles (about 90 %) was transferred to the tissue. After slicing the tissue, the rather spherical distribution of nanoparticles may be illustrated. Afterward, that circulation at the rate equal to blood perfusion has been made to simulate blood perfusion in dead tissue. To measure temperature, seven Lm35 sensors have been inserted into the tissue to report temperature differences. Based on results, there was seen a significant change in hyperthermic temperature difference in comparison with results obtained from Pennes' bioheat transfer equation. Additionally, a difference of about 5-10 % was seen between numerical and experimental results.
机译：本研究的目的是通过药物递送检查血液灌注在磁性流体热疗中的作用。虽然由于高局部温差导致的血液灌注是指人体的智能反应，但一些研究人员习惯于在生物健康转移方程中采用恒定的血液灌注速率。在这项研究中，我们考虑了组织中血液灌注的可变体积速率，通过Galerkin方法实验和数值。为了验证从数值方法获得的结果，提出了一种实验程序。此外，为了通过药物递送转移磁流体，使用通过静脉和动脉纳米颗粒的盐水血清的输注覆盖物在组织中形成球形分布。该循环使得可以在没有任何注射的情况下将纳米颗粒转移到组织中。 60分钟后，将盐水血清的暗颜色改为透明，将大量的纳米颗粒（约90％）转移到组织中。在切割组织之后，可以说明纳米颗粒的相当球形分布。之后，已经进行了等于血液灌注的速率的循环以模拟死组织中的血液灌注。为了测量温度，已将七个LM35传感器插入组织中以报告温度差异。基于结果，与从Pennes生物发热方程获得的结果相比，在高温温度差异中看到了显着变化。另外，在数值和实验结果之间看到约5-10％的差异。

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