...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Macromolecular Science. Pure and Applied Chemistry >Investigation of a novel thermogelling hydrogel for a versatility of drugs delivery
【24h】

Investigation of a novel thermogelling hydrogel for a versatility of drugs delivery

机译：调查一种新型热凝胶水凝胶，用于药物递送的多功能性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The P(CL-PDO)-PEG-(P(CL-PDO)(PECP) copolymer hydrogel is an attractive thermogelling material for practical applications due to the fast dissolution of the copolymer in water and good stability of the resultant sol solution that is beneficial for guest matter mixing. In this paper, the degradation properties and drug release behavior of the hydrogel loaded with various types of drugs were evaluated. The integrity of the PECP hydrogel could preserve for 2 weeks and became viscous liquid after degradation time of 21 weeks. With the degradation time, both the molecular weight and weight loss of the hydrogel decreased gradually. NMR analysis of the degraded products indicated that the chain breaking of the copolymer mainly occurred within the sequence structures of PDO-PDO or PDO-PCL, implying the acceleration effect of PDO unit to the degradation of hydrogel. Three distinct types of drugs including small molecular hydrophobic, small molecular hydrophilic and hydrophilic macromolecular drugs were loaded into the PECP hydrogel to evaluate their release profiles. The result showed that the releasing periods for macromolecular protein or hydrophobic drug were extended to more than one month. Since these two types of drugs are loaded within different regions of the hydrogel due to their different hydrophobic/hydrophilic nature, the PECP hydrogel is expected to develop injectable system loaded with a versatility of drugs or guest matter for synergetic effect.
机译：P（Cl-PDO）-PEG-（P（CL-PDO）（PECP）共聚物水凝胶是一种具有吸引力的热凝胶材料，用于实际应用，由于共聚物在水中的快速溶解和所得溶胶溶液的良好稳定性对客观混合有益。在本文中，评估了用各种类型药物负载的水凝胶的降解性能和药物释放行为。PECP水凝胶的完整性可以保持2周，并在21周的降解时间后变成粘性液体。随着劣化时间，水凝胶的分子量和体重减轻逐渐减少。降解产物的NMR分析表明，共聚物的链断分解主要发生在PDO-PDO或PDO-PCL的序列结构内，暗示PDO单元对水凝胶降解的加速效应。三种不同类型的药物，包括小分子疏水性，小分子亲水和亲水性大分子德鲁将GS加载到PECP水凝胶中以评估释放型材。结果表明，大分子蛋白质或疏水药的释放期延长至超过一个月。由于由于其不同的疏水性/亲水性质，这两种类型的药物在水凝胶的不同区域内装载，因此预计PECP水凝胶将开发出可注射系统，其具有含有药物或访客的多功能性，以获得协同作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号