First hyperpolarized [2-C-13]pyruvate MR studies of human brain metabolism

Chung Brian T.; Chen Hsin-Yu; Gordon Jeremy; Mammoli Daniele; Sriram Renuka; Autry Adam W.; Le Page Lydia M.; Chaumeil Myriam M.; Shin Peter; Slater James; Tan Chou T.; Suszczynski Chris; Chang Susan; Li Yan; Bok Robert A.; Ronen Sabrina M.; Larson Peder E. Z.; Kurhanewicz John; Vigneron Daniel B.

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First hyperpolarized [2-C-13]pyruvate MR studies of human brain metabolism

机译：第一次超极化[2-C-13]丙酮化物研究人脑新陈代谢研究

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We developed methods for the preparation of hyperpolarized (HP) sterile [2-C-13]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human cerebral energy metabolism by measuring the dynamic conversion of HP [2-C-13]pyruvate to [2-C-13]lactate and [5-C-13]glutamate in the brain of four healthy volunteers. Metabolite kinetics, signal-to-noise (SNR) and area-undercurve (AUC) ratios, and calculated [2-C-13]pyruvate to [2-C-13]lactate conversion rates (k(PL)) were measured and showed similar but not identical inter-subject values. The k(PL) measurements were equivalent with prior human HP [1-C-13]pyruvate measurements. (C) 2019 Elsevier Inc. All rights reserved.

机译：我们开发了制备超极化（HP）无菌[2-C-13]丙酮酸的方法，以在FDA-IND和IRB批准之后在首次进行第一人体NMR研究中测试其可行性。使用该MR稳定同位素成像方法的光谱结果证明了通过测量HP [2-C-13]丙酮酸丙酮酸的动态转化和[5-C-13]的动态转化来研究人脑能量代谢的可行性。[5-C-13 ]谷氨酸在四个健康志愿者的大脑中。测定代谢物动力学，信号对噪声（SNR）和区域腹水（AUC）比率，并计算[2-C-13]丙酮酸至[2-C-13]乳酸转化率（K（PL））显示出类似但没有相同的对象间值。 K（PL）测量与先前的人HP [1-C-13]丙酮酸液测量相同。（c）2019 Elsevier Inc.保留所有权利。

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来源
《Journal of magnetic resonance》 |2019年第2019期|共7页
作者
Chung Brian T.; Chen Hsin-Yu; Gordon Jeremy; Mammoli Daniele; Sriram Renuka; Autry Adam W.; Le Page Lydia M.; Chaumeil Myriam M.; Shin Peter; Slater James; Tan Chou T.; Suszczynski Chris; Chang Susan; Li Yan; Bok Robert A.; Ronen Sabrina M.; Larson Peder E. Z.; Kurhanewicz John; Vigneron Daniel B.;
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作者单位

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Merck KGaA ISOTEC Stable Isotope Div MilliporeSigma Miamisburg OH 45342 USA;

Merck KGaA ISOTEC Stable Isotope Div MilliporeSigma Miamisburg OH 45342 USA;

Univ Calif San Francisco Dept Med San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

Univ Calif San Francisco Dept Radiol &

Biomed Imaging 1700 Fourth St Byers Hall Suite 102 San Francisco CA 94158 USA;

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原文格式 PDF
正文语种 eng
中图分类 O82.532;
关键词
Hyperpolarized C13; Metabolic imaging; Brain metabolism;

机译：超极化C13;代谢成像;脑新陈代谢;

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专利

1. First hyperpolarized [2-C-13]pyruvate MR studies of human brain metabolism [J] . Chung Brian T., Chen Hsin-Yu, Gordon Jeremy, Journal of magnetic resonance . 2019,第期

机译：第一次超极化[2-C-13]丙酮化物研究人脑新陈代谢研究
2. Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain [J] . IEEE Transactions on Medical Imaging . 2020,第2期

机译：人脑中超极化碳13丙酮酸代谢的动力学模型
3. Quantifying normal human brain metabolism using hyperpolarized [1-C-13] pyruvate and magnetic resonance imaging [J] . Grist James T., McLean Mary A., Riemer Frank, NeuroImage . 2019,第期

机译：使用超极化的[1-C-13]丙酮酸和磁共振成像来定量正常人脑代谢
4. Tryptophan metabolism via serotonin in human CSFof different brain sites using a newneuroendoscopic technique [C] . P. Longatti, S. Comai, A. Perin, International Study Group for Tryptophan Research . 2007

机译：使用婴儿透视技术，通过血清素在人类CSFOF中的血清素的色氨酸新陈代谢
5. Dynamic interleaved imaging of pyruvate metabolism with hyperpolarized carbon-13. [D] . Leung, Kevin Kai-Chi. 2010

机译：丙酮酸代谢与超极化碳13的动态交错成像。
6. Hyperpolarized 13C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1 T [O] . Vesselin Z. Miloushev, Valentina Di Gialleonardo, Lucia Salamanca-Cardona, -1

机译：1T时具有吸收模式EPSI的超极化13C丙酮酸小鼠大脑新陈代谢
7. Hyperpolarized 13 C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1 T [O] . Vesselin Z. Miloushev, Valentina Di Gialleonardo, Lucia Salamanca-Cardona, 2017

机译：高极化的13℃丙酮酸小鼠脑代谢与吸收模式EPSI在1吨

First hyperpolarized [2-C-13]pyruvate MR studies of human brain metabolism

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