• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of microbiology, immunology, and infection: Wei mian yu gan ran za zhi >Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta.
【24h】

Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta.

机译：Cetirizine和LorataDine对白细胞介素-1beta刺激的A549人气道上皮细胞粒细胞 - 巨噬细胞刺激因子和白细胞介素-8释放的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: In addition to being antagonists of histamine receptors, some antihistamines modulate the pathogenesis of allergic inflammation by reducing mediator release, adhesion molecule expression and, consequently, recruitment of inflammatory cells. The aim of this study was to explore the effects of 2 second-generation antihistamines, cetirizine and loratadine, on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-8 (IL-8) secretions in human airway epithelial cells. METHODS: A549 cells were pre-incubated with cetirizine (1, 5, 10 muM) or loratadine (1 muM) individually for 16 h followed by stimulation with IL-1beta for 8 h. The levels of GM-CSF and IL-8 were measured by an enzyme-linked immunosorbant assay. RESULTS: Cetirizine (10 muM) and loratadine significantly reduced the release of GM-CSF, by 37% and 40%, respectively (p<0.05). Cetirizine (5, 10 muM) inhibited the production of IL-8 by 19% (p<0.05). However, cetirizine (1 muM) and loratadine (1 muM) did not appreciably inhibit IL-8 release. CONCLUSIONS: These observations indicate that these 2 second-generation antihistamines inhibit the release of GM-CSF and IL-8 beyond their antagonistic histamine H1 receptor activity and may thus exert clinically relevant anti-inflammatory effects in inflammatory airway disorders.
机译：背景和目的：除了组胺受体的拮抗剂外，一些抗组胺药通过减少介质释放，粘附分子表达，并因此募集炎症细胞来调节过敏性炎症的发病机制。本研究的目的是探讨2个第二代抗组胺药，即甲嘧啶和洛拉啶，在人类气道上皮细胞中造粒细胞 - 巨噬细胞刺激因子（GM-CSF）和白细胞介素-8（IL-8）分泌物的影响。方法：将A549细胞单独预孵育16小时，然后用IL-1Beta刺激8小时。通过酶联免疫吸收剂测定法测量GM-CSF和IL-8的水平。结果：香蒲（10毫米）和洛拉啶显着降低了GM-CSF的释放，分别为37％和40％（P <0.05）。香嗪（5,10毫米）抑制IL-8的生产19％（P <0.05）。然而，十六嗪（1妈妈）和洛拉啶（1妈妈）并未明显抑制IL-8释放。结论：这些观察结果表明，这2个第二代抗组胺药抑制了GM-CSF和IL-8之外的释放超出其拮抗组胺H1受体活性，因此可以在炎性气道疾病中发挥临床相关的抗炎作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号