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首页> 外文期刊>Journal of Medical Virology >Correlation between serum matrix metalloproteinase and antigenemia levels in patients infected with rotavirus
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Correlation between serum matrix metalloproteinase and antigenemia levels in patients infected with rotavirus

机译：旋转病毒感染患者血清基质金属蛋白酶和抗原血症水平的相关性

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摘要

Rotavirus (RV) antigenemia has been reported in patients with gastroenteritis; however, the exact mechanism remains unclear. In order to elucidate the mechanism of RV antigenemia, an association between RV antigenemia and matrix metalloproteinase (MMP) were analyzed. The object of this study was to elucidate the role of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in the pathogenesis of RV antigenemia. Forty children admitted to hospital with RV gastroenteritis were enrolled in this study. Paired serum samples were collected at the time of admission and discharge. Enzyme-linked immunosorbent assays (ELISA) were used to detect serum concentrations of viral antigens, MMP-1, -2, -9, -13, TIMP -1, and -2. Cytokines were measured using flow cytometric beads array. RV antigens were significantly higher in serum collected at the time of admission than discharge (P<0.001). MMP-9 concentrations were significantly higher in serum collected at the time of admission than discharge (P<0.001). MMP-2 concentrations were significantly lower in serum collected at the time of admission than discharge (P<0.001). A weak but a significantly positive association (P=0.034) was observed between RV antigen and MMP-9 in serum collected at the time of admission, and inverse association was observed between RV antigen and MMP-2. In addition, a weak but significantly positive association (P=0.002) was observed between IL-6 and MMP-9. These data suggest that MMPs may contribute to the pathogenesis of RV antigenemia.
机译：胃肠炎患者报道了RotaVirus（RV）抗原血症;但是，确切的机制仍然不清楚。为了阐明RV抗原血症的机制，分析了RV抗原血症和基质金属蛋白酶（MMP）之间的关联。本研究的目的是阐明MMP和组织抑制剂在RV抗原血症发病机制中的MMP和组织抑制剂的作用。本研究报名参加了患有RV胃肠炎医院的四十名儿童。在入院和放电时收集成对的血清样品。酶联免疫吸附试验（ELISA）用于检测病毒抗原，MMP-1，-2，-9，-13，TIMP -1和-2的血清浓度。使用流式细胞术珠阵列测量细胞因子。在入院时比放电时收集的血清中的RV抗原显着较高（P <0.001）。在入院时收集的血清中的MMP-9浓度显着较高（P <0.001）。在入院时收集的血清中MMP-2浓度显着降低（P <0.001）。在入院时收集的血清中收集的RV抗原和MMP-9之间观察到弱但显着的阳性关联（P = 0.034），并且在RV抗原和MMP-2之间观察到逆关联。此外，在IL-6和MMP-9之间观察到弱但显着的阳性关联（P = 0.002）。这些数据表明MMP可能有助于RV抗原血症的发病机制。

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  • 来源
    《Journal of Medical Virology》 |2012年第6期|共6页
  • 作者

    KawamuraY.; SugataK.; NakaiH.; AsanoY.; OhashiM.; KatoT.; NishimuraN.; OzakiT.; YuiA.; TaniguchiK.; YoshikawaT.;

  • 作者单位

    Department of Pediatrics Fujita Health University School of Medicine Toyoake Aichi Japan;

    Department of Pediatrics Fujita Health University School of Medicine Toyoake Aichi Japan;

    Department of Pediatrics Fujita Health University School of Medicine Toyoake Aichi Japan;

    Department of Pediatrics Fujita Health University School of Medicine Toyoake Aichi Japan;

    Department of Pediatrics Toyokawa Municipal Hospital Toyokawa Aichi Japan;

    Department of Pediatrics Toyokawa Municipal Hospital Toyokawa Aichi Japan;

    Department of Pediatrics Konan Kosei Hospital Konan Aichi Japan;

    Department of Pediatrics Konan Kosei Hospital Konan Aichi Japan;

    Department of Virology and Parasitology Fujita Health University School of Medicine Toyoake;

    Department of Virology and Parasitology Fujita Health University School of Medicine Toyoake;

    Department of Pediatrics Fujita Health University School of Medicine Toyoake Aichi Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学微生物学（病原细菌学、病原微生物学）;
  • 关键词

    Antigenemia; MMP; Rotavirus; TIMP;

    机译：抗原血症;MMP;轮状病毒;TIMP;

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