Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages

Huang Yuan; Liu Lingling; Ma Di; Liao Yi; Lu Yuanyuan; Huang Heyu; Qin Wenqing; Liu Xinglou; Fang Feng

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Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages

机译：人巨细胞病毒在THP-1衍生的巨噬细胞中触发AIM2炎症的组装

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Absent in melanoma 2 (AIM2) inflammasome is a multiprotein complex which plays a pivotal role in the host immune response to multiple pathogens. The role of AIM2 in human cytomegalovirus (HCMV) infection is poorly studied. Thus, using a small inference RNA (siRNA) approach and THP-1 derived macrophage cells infected with HCMV AD169 strain, we investigated the impact of HCMV infection on AIM2-mediated molecular events. Compared to wild-type cells, AIM2-defiecient macrophages showed a limited ability to activate caspase-1, process IL-1 beta, and induce cell death. In addition, AIM2-defiecient cells were unable to efficiently control HCMV infection, as the transcription of virus DNA polymerase gene UL54 and major tegument protein gene UL83 were higher compared to wild-type cells. In conclusion, HCMV infection induces an AIM2 inflammasome response, which negatively influences viral life cycle.

机译：在黑色素瘤2（AIM2）中缺席（AIM2）炎症是一种多蛋白复合物，其在宿主免疫应答对多种病原体中起着枢转作用。 AIM2在人巨细胞病毒（HCMV）感染中的作用很差。因此，使用用HCMV Ad169菌株感染的小推理RNA（siRNA）方法和THP-1衍生的巨噬细胞细胞，我们研究了HCMV感染对AIM2介导的分子事件的影响。与野生型细胞相比，AIM2 - 抗原因巨噬细胞显示出激活Caspase-1的有限能力，加工IL-1β并诱导细胞死亡。此外，AIM2 - 缩小细胞不能有效地控制HCMV感染，因为与野生型细胞相比，病毒DNA聚合酶基因UL54和主要Tegument蛋白基因UL83的转录均高。总之，HCMV感染诱导AIM2炎症组响应，对病毒生命周期产生负面影响。

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《Journal of Medical Virology》 |2017年第12期|共8页
作者
Huang Yuan; Liu Lingling; Ma Di; Liao Yi; Lu Yuanyuan; Huang Heyu; Qin Wenqing; Liu Xinglou; Fang Feng;
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作者单位

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

Huazhong Univ Sci &

Technol Tongji Med Coll Tongji Hosp Dept Pediat Wuhan Hubei Peoples R;

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原文格式 PDF
正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
human cytomegalovirus; innate immunity; interleukin; siRNA;

机译：人巨细胞病毒;先天免疫;白细胞介素;siRNA;

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专利

1. Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages [J] . Huang Yuan, Liu Lingling, Ma Di, Journal of Medical Virology . 2017,第12期

机译：人巨细胞病毒在THP-1衍生的巨噬细胞中触发AIM2炎症的组装
2. Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages [J] . Yuri Song, Hee Sam Na, Eunjoo Park, International journal of oral science . 2018,第3期

机译：变形链球菌激活人类THP-1巨噬细胞中的AIM2，NLRP3和NLRC4炎性小体
3. Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages [J] . Yuri Song, Hee Sam Na, Eunjoo Park, 国际口腔科学杂志（英文版） . 2018,第003期

机译：变形链球菌激活人THP-1巨噬细胞中的AIM2，NLRP3和NLRC4炎性小体
4. Does Metal Ion-induced Oxidative Stress Activate the Inflammasome in Macrophages? [C] . Maxime-Alexandre Ferko, Kriti Kumar, Isabelle Catelas Society for Biomaterials annual meeting and exposition . 2017

机译：金属离子诱导的氧化应激会激活巨噬细胞中的炎性体吗？
5. Molecular recognition of DNA by the AIM2 inflammasome induces neuronal pyroptosis: Implications in infection and host tissue damage [D] . Adamczak, Stephanie E. 2012

机译：AIM2炎症小体对DNA的分子识别可诱导神经元焦磷酸化：对感染和宿主组织损伤的影响
6. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome [O] . Sara Botto, Jinu Abraham, Nobuyo Mizuno, 2019

机译：人类巨细胞病毒立即早期86 kDa蛋白阻止转录并在病毒体介导的AIM2炎症小体激活过程中诱导未成熟白介素1β蛋白的降解。
7. 351 Autoimmune-associated gene clec16a regulates nlrp3 but not aim2 inflammasome pathway in human macrophages [O] . WMM Li, ALY Yim, VSF Chan, 2017

机译：351自身免疫相关基因Clec16A调节NLRP3但不是人类巨噬细胞的AIM2炎症途径

Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages

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