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首页> 外文期刊>Journal of Medical Virology >Evidence of increasing diversification of Zika virus strains isolated in the American continent
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Evidence of increasing diversification of Zika virus strains isolated in the American continent

机译:增加Zika病毒菌株在美国大陆中分离的多样化的证据

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摘要

Zika virus (ZIKV) is a member of the family Flaviviridae. ZIKV emerged in Brazil in 2015, causing an unprecedented epidemic and since then the virus has rapidly spread throughout the Americas. These facts highlight the need of detailed phylogenetic studies to understand the emergence, spread, and evolution of ZIKV populations. For these reasons, a Bayesian coalescent Markov Chain Monte Carlo analysis of complete genome sequences of ZIKV strains recently isolated in the American continent was performed. The results of these studies revealed an increasing diversification of ZIKV strains in different genetic lineages and co-circulation of distinct genetic lineages in several countries in the region. The time of the most recent common ancestor (tMRCA) was established to be around February 20, 2014 for ZIKV strains circulating in the American region. A mean rate of evolution of 1.55x10(-3) substitutions/site/year was obtained for ZIKV strains included in this study. A Bayesian skyline plot indicate a sharp increase in population size from February 2014 to July 2015 and a decline during 2016. These results are discussed in terms of the emergence and evolution of ZIKV populations in the American continent.
机译:Zika病毒(ZIKV)是Flaviviridae的成员。 ZIKV在2015年出现在巴西,造成前所未有的流行病,从那时起,病毒在整个美洲迅速传播。这些事实突出了详细的系统发育研究,以了解ZIKV种群的出现,传播和演化。出于这些原因,贝叶斯泛腾马尔可夫链蒙特卡罗在美国大陆中孤立的Zikv菌株完全基因组序列分析。这些研究的结果揭示了在该地区几个国家的不同遗传谱系中的ZIKV菌株的多样化,并在该地区的几个国家的不同遗传谱系。最近常见的祖先(TMRCA)的时间成立于2014年2月20日左右,用于在美国地区流传的ZIKV菌株。在本研究中包含的ZIKV菌株获得1.55x10(-3)级替代/位点/年的平均演化速度。贝叶斯天际线情节表明2014年2月至2015年7月的人口大小急剧增加,2016年的下降。这些结果在美国大陆的ZIKV人口的出现和演变方面讨论。

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