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首页> 外文期刊>Journal of Medical Virology >Role of gamma delta T cells in exacerbated airway inflammation during reinfection of neonatally primed mice in adulthood
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Role of gamma delta T cells in exacerbated airway inflammation during reinfection of neonatally primed mice in adulthood

机译：Gamma Delta T细胞在Adulthood在新生儿初步小鼠中加剧期间的气道炎症中的作用

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Age at primary infection with respiratory syncytial virus (RSV) is a crucial factor in determining the outcome of reinfection. However, how neonatal RSV infection affects the immune system and renders the host more susceptible to reinfection in later life is poorly understood. In the present study, by using BALB/c mice that were first infected with RSV as neonates, the role of gamma delta T cells in the development of airway inflammation during reinfection in adulthood was investigated. We found that neonatal RSV infection resulted in an aggravated infiltration of mononuclear cells in bronchoalveolar lavage (BAL) fluids, in parallel with a significant increase in the levels of type 2 cytokines in lungs on day 4 after reinfection. Since the numbers of total gamma delta T cells as well as activated gamma delta T cells, particularly IL-4-, IL-5-, and IL-13-producing gamma delta T cells, were enhanced markedly in the lungs of neonatally primed mice, we speculate that gamma delta T cells might participate in the augmented airway inflammation seen during reinfection. Indeed, depletion of gamma delta T cells attenuated the severity of lung histopathology during reinfection. Meanwhile, treatment of neonatal mice with anti-TCR mAb diminished not only the numbers of neutrophils, eosinophils, and lymphocytes, but also the levels of IL-4, IL-5, and IL-13 in the lungs after reinfection in adulthood, suggesting that gamma delta T cells, particularly Th2-type gamma delta T cells might play a critical role in exacerbating the pulmonary tissue pathology during reinfection of adult mice that were first infected as neonates.
机译：呼吸道合胞病毒（RSV）原发性感染的年龄是测定重新凝聚结果的关键因素。然而，新生儿RSV感染如何影响免疫系统，并且渲染在后期生活中更容易再现的宿主更令人难以理解。在本研究中，通过使用首次感染RSV作为新生儿的BALB / C小鼠，研究了γδTT细胞在成年期再灌注期间气道炎症发展中的作用。我们发现新生儿RSV感染导致支气管肺泡灌洗（BAL）流体中单核细胞的加重渗透，并平行于再感染后第4天在第4天在第4天肺中2细胞因子的含量显着增加。由于新生儿灌注小鼠的肺部，因此在新生儿底次小鼠的肺部中显着增强了总γδT细胞以及特别是IL-4-，IL-5-和IL-13的γδTET细胞的γδTT细胞的数量，我们推测γδt细胞可能参与在重新感染期间看到的增强气道炎症。实际上，γδT细胞的耗竭衰减在重新灌染过程中肺组织病理学的严重程度。同时，用抗TCR MAb治疗新生儿小鼠的嗜嗜酸性粒细胞，嗜酸性粒细胞和淋巴细胞的数量，而且减少了在成年期再次加入后肺部的IL-4，IL-5和IL-13的水平，提示该γδT细胞，特别是Th2型γδT细胞可能在加剧肺组织病理过程中在首次被感染为新生儿的成人小鼠期间发挥关键作用。

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