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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >Synthetic poly(vinyl alcohol)-chitosan as a new type of highly efficient hemostatic sponge with blood-triggered swelling and high biocompatibility
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Synthetic poly(vinyl alcohol)-chitosan as a new type of highly efficient hemostatic sponge with blood-triggered swelling and high biocompatibility

机译：合成聚（乙烯醇） - 作为一种新型高效止血海绵，具有血触发肿胀和高生物相容性的新型高效止血海绵

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摘要

Rapid and effective hemostasis for a noncompressible hemorrhage is the key to control bleeding and reduce mortality. Chitosan (CS) has been widely used as a popular hemostatic dressing; however, irregularly shaped wounds present in emergencies limit the performance of CS powder. To improve the hemostatic effect of CS, we modified it with poly(vinyl alcohol) (PVA), a fast-swelling sponge triggered by water. The novel synthetic PVA-CS was prepared by cross-linking PVA and CS during foaming and crosslinking reactions. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction were utilized to analyze the characteristics of PVA-CS. In vitro, the swelling ratio and blood clotting ability were evaluated in different groups with various weight ratios or degrees of deacetylation of the CS, and the cytocompatibility and cell attachment on the material were analyzed by human dermal fibroblast (HDF) cell testing. In vivo, the hemostatic effects were evaluated in Sprague-Dawley rats and Bama miniature pigs in a femoral artery hemorrhage model or gunshot wound experiment. PVA-CS presents robust mechanical strength, rapid water-triggered swelling and a fast absorption speed. As compared with gauze and PVA, which are widely used in first aid, PVA-CS sponges showed an improved blood clotting ability and increased blood cell and platelet adhesion and activation. The PVA-CS sponges also showed high biocompatibility in cell viability, cell proliferation and cell attachment bioassays. Furthermore, in vivo evaluation of the PVA-CS sponges revealed excellent hemostatic performance and enhanced wound healing with increased re-epithelialization and decreased granulation tissues. The results of this study strongly support the use of these composite sponges for noncompressible hemorrhage in acute trauma and ballistic injuries.
机译：用于不可抑制的出血的快速有效的止血是控制出血和降低死亡率的关键。壳聚糖（CS）已被广泛用作普遍的止血敷料;然而，紧急情况下存在的不规则形状的伤口限制了Cs粉末的性能。为了提高CS的止血作用，我们用聚（乙烯醇）（PVA）改性它，一种被水触发的快速膨胀海绵。通过在发泡和交联反应期间交联PVA和CS来制备新的合成PVA-CS。利用傅里叶变换红外光谱（FTIR），扫描电子显微镜（SEM）和X射线衍射分析PVA-CS的特性。体外，在不同的基团中评价溶胀比和血液凝血能力，具有各种重量比或CS的脱乙酰化程度，并通过人的皮肤成纤维细胞（HDF）细胞测试分析材料上的细胞相容性和细胞附着。体内，在Sprague-Dawley大鼠和Bama微型猪中评估了止血效果在股动脉出血模型或枪击伤口实验中。 PVA-CS呈现强大的机械强度，快速的水触发肿胀和快速吸收速度。与纱布和PVA相比，PVA-CS海绵被广泛使用，PVA-CS海绵显示出改善的血液凝血能力和血液细胞增加和血小板粘附和活化。 PVA-CS海绵还表现出细胞活力，细胞增殖和细胞附着物的生物相容性的高生物相容性。此外，在PVA-CS海绵的体内评估中显示出优异的止血性能和增强的伤口愈合随着再上皮和造粒组织而降低而增加。这项研究的结果强烈支持这些复合海绵在急性创伤和弹道损伤中使用这些复合海绵。

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    Zhao Yi-Fan; Zhao Jing-Yu; Hu Wen-Zhi; Ma Kui; Chao Yong; Sun Peng-Jun; Fu Xiao-Bing; Zhang Hong;

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    Chinese PLA Sch Med Dept Anesthesiol Beijing 100853 Peoples R China;

    Chinese PLA Sch Med Dept Anesthesiol Beijing 100853 Peoples R China;

    Peoples Liberat Army Gen Hosp Wound Healing Unit Beijing 100853 Peoples R China;

    Peoples Liberat Army Gen Hosp Wound Healing Unit Beijing 100853 Peoples R China;

    Peoples Liberat Army Gen Hosp Affiliated Hosp 1 Dept Med Engn Beijing 100048 Peoples R China;

    Peoples Liberat Army Gen Hosp Affiliated Hosp 1 Dept Gen Sugery Beijing 100048 Peoples R China;

    Peoples Liberat Army Gen Hosp Wound Healing Unit Beijing 100853 Peoples R China;

    Peoples Liberat Army Gen Hosp Dept Anesthesiol Beijing 100853 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分析化学;
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