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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >From cells-on-a-chip to organs-on-a-chip: scaffolding materials for 3D cell culture in microfluidics
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From cells-on-a-chip to organs-on-a-chip: scaffolding materials for 3D cell culture in microfluidics

机译：从芯片上的电池到芯片上的芯片：微流体中用于3D细胞培养的脚手架材料

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摘要

It is an emerging research area to integrate scaffolding materials in microfluidic devices for 3D cell culture (organs-on-a-chip). The technology of organs-on-a-chip holds the potential to obviate the gaps between pre-clinical and clinical studies. As accumulating evidence shows the importance of extracellular matrix inin vitrocell culture, significant efforts have been made to integrate 3D ECM/scaffolding materials in microfluidics. There are two families of materials that are commonly used for this purpose: hydrogels and electrospun fibers. In this review, we briefly discuss the properties of the materials, and focus on the various technologies to obtain the materials (e.g.extraction of collagen from animal tissues) and to include the materials in microfluidic devices. Challenges and potential solutions of the current materials and technologies were also thoroughly discussed. At the end, we provide a perspective on future efforts to make these technologies more translational to broadly benefit pharmaceutical and pathophysiological research.
机译：它是一种新兴的研究区，用于将脚手架材料整合在微流体装置中的3D细胞培养物（芯片碎片）。器官芯片技术占据了临床前和临床研究之间的差距的可能性。由于累积证据表明，vitrocell培养细胞外基质的重要性，已经进行了大量努力，以在微流体中整合3D ECM /脚手架材料。有两个常用的材料常用于此目的：水凝胶和电纺纤维。在本文中，我们简要讨论了材料的性质，并专注于各种技术，以获得材料（例如来自动物组织的胶原蛋白的胶原蛋白）并包括微流体装置中的材料。还彻底讨论了目前材料和技术的挑战和潜在解决方案。最后，我们提供了未来努力的视角，使这些技术更加平移，以广泛利用药物和病理生理学研究。

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