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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy
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Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

机译：新型酞菁基聚合物胶束，具有高近红外光热转化效率的808 nm激光照射，用于体内癌症治疗

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摘要

Photothermal therapy (PTT) has emerged as one of the promising methodologies for the treatment of cancer, and ideal photothermal agents need to be biodegradable and have strong optical absorbance in the near-infrared (NIR) optical window. Here, we report a new phthalocyanine molecule, 4OCSPC, which expands the absorbance edge to 850 nm. Under 808 nm NIR laser irradiation, 4OCSPC polymeric micelles showed robust photostability and a high photothermal conversion of 47.0%. Also, the 4OCSPC polymeric micelles exhibit a high in vivo PTT efficacy against 4T1 tumors in mice.
机译：光热疗（PTT）已成为治疗癌症的有希望的方法之一，并且理想的光热试剂需要可生物降解，并且在近红外（NIR）光学窗口中具有强光学吸光度。 在这里，我们报告了一种新的酞菁分子，4ocspc，使吸光度边缘扩展至850nm。 在808nm Nir激光照射下，4ocspc聚合物胶束显示出牢固的光稳定性和47.0％的高光热转化率。 此外，4ocspc聚合物胶束在小鼠中对4T1肿瘤的体内PTT功效表现出高。

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    Li Lu; Yang Qingzhu; Shi Lei; Zheng Nannan; Li Zeyu; Li Kai; Qiao Shupei; Jia Tao; Sun Tiedong; Wang Yue;

  • 作者单位

    Northeast Forestry Univ Dept Chem Coll Sci 26 Hexing Rd Harbin 150040 Heilongjiang Peoples R China;

    Harbin Inst Technol Sch Life Sci &

    Technol Harbin 150080 Heilongjiang Peoples R China;

    Northeast Forestry Univ Dept Chem Coll Sci 26 Hexing Rd Harbin 150040 Heilongjiang Peoples R China;

    Harbin Inst Technol Sch Life Sci &

    Technol Harbin 150080 Heilongjiang Peoples R China;

    Northeast Forestry Univ Dept Chem Coll Sci 26 Hexing Rd Harbin 150040 Heilongjiang Peoples R China;

    Harbin Inst Technol Sch Life Sci &

    Technol Harbin 150080 Heilongjiang Peoples R China;

    Harbin Inst Technol Sch Life Sci &

    Technol Harbin 150080 Heilongjiang Peoples R China;

    Northeast Forestry Univ Dept Chem Coll Sci 26 Hexing Rd Harbin 150040 Heilongjiang Peoples R China;

    Northeast Forestry Univ Dept Chem Coll Sci 26 Hexing Rd Harbin 150040 Heilongjiang Peoples R China;

    Jilin Univ Coll Chem State Key Lab Supramol Struct &

    Mat Qianjin St Changchun Jilin Peoples R China;

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  • 正文语种 eng
  • 中图分类 分析化学;
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